EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS
Background: Diabetes mellitus is a chronic metabolic disorder with major complication of delayed wound healing. Objectives: The purpose of this study was to evaluate the effect of sildenafil on blood glucose level, body weight and leucocyte count during wound healing in diabetic rats. Method: Forty-...
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Ntec Specialist
2016-01-01
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| Series: | Kanem Journal of Medical Sciences |
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| Online Access: | https://kjmsmedicaljournal.com/wp-content/uploads/2019/09/2_-Ngulde-SI_et-al_KJMSvol10n1.pdf |
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| author | Ngulde SI Umaru B Mahre MB William A Agbutun PA Midda YH Atela PE Daniel HM Giwa-Imam LN |
| author_facet | Ngulde SI Umaru B Mahre MB William A Agbutun PA Midda YH Atela PE Daniel HM Giwa-Imam LN |
| author_sort | Ngulde SI |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a chronic metabolic disorder with major complication of delayed wound healing. Objectives: The purpose of this study was to evaluate the effect of sildenafil on blood glucose level, body weight and leucocyte count during wound healing in diabetic rats. Method: Forty-two Albino rats randomly divided into 7 groups of 6 rats per group were treated orally with sildenafil (50 mg/kg) for 21 days and/or single dose of intraperitoneal injection of insulin (10 I.U.). Before treatments, diabetes was induced in groups A, B, C and D by a single intraperitoneal injection of alloxan (130mg/kg) and a square-shaped wound measuring 1.5cm was created under anesthesia on the dorsum of rats in all groups except group G. The rats in group A were treated with sildenafil citrate orally at the dose rate of 50 mg/kg body weight for 21 days and the rats in group B were treated with insulin injection of 10 international units once and sildenafil citrate as in Group A. The rats in group C were treated with only insulin injection of 10 international units once and the rats in group D were treated with only distilled water. Groups E and F were nondiabetic rats with wounds similar to those of diabetic rats in the previous groups and each rat in group E was also treated with sildenafil citrate as in Group A and those in group F were treated with only distilled water. The rats in Group G were normal rats without wound treated with sildenafil citrate as in Group A. Data collected were analysed using SPSS version 20. Results: The results indicated that sildenafil causes a nonsignificant (P greater than 0.05) decrease in the blood glucose of diabetic rats, a significant (P less than 0.05) increase in the leucocyte count and a significant decrease (p less than 0.05) in the rate of percentage decrease in body weight. Conclusion: Sildenafil may have the potential of reducing the rate of body weight loss in diabetic rats (with or without wound) receiving insulin treatment |
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| issn | 2006-4772 2714-2426 |
| language | English |
| last_indexed | 2024-04-11T18:29:50Z |
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| series | Kanem Journal of Medical Sciences |
| spelling | doaj.art-7c30a0c32d7e4f2d8a16b08a8d673c932022-12-22T04:09:29ZengNtec SpecialistKanem Journal of Medical Sciences2006-47722714-24262016-01-01101132020161EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATSNgulde SI0Umaru B1Mahre MB2William A3Agbutun PA4Midda YH5Atela PE6Daniel HM7Giwa-Imam LN8Department of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriDepartment of Veterinary Physiology, Pharmacology and Biochemistry, University of MaiduguriBackground: Diabetes mellitus is a chronic metabolic disorder with major complication of delayed wound healing. Objectives: The purpose of this study was to evaluate the effect of sildenafil on blood glucose level, body weight and leucocyte count during wound healing in diabetic rats. Method: Forty-two Albino rats randomly divided into 7 groups of 6 rats per group were treated orally with sildenafil (50 mg/kg) for 21 days and/or single dose of intraperitoneal injection of insulin (10 I.U.). Before treatments, diabetes was induced in groups A, B, C and D by a single intraperitoneal injection of alloxan (130mg/kg) and a square-shaped wound measuring 1.5cm was created under anesthesia on the dorsum of rats in all groups except group G. The rats in group A were treated with sildenafil citrate orally at the dose rate of 50 mg/kg body weight for 21 days and the rats in group B were treated with insulin injection of 10 international units once and sildenafil citrate as in Group A. The rats in group C were treated with only insulin injection of 10 international units once and the rats in group D were treated with only distilled water. Groups E and F were nondiabetic rats with wounds similar to those of diabetic rats in the previous groups and each rat in group E was also treated with sildenafil citrate as in Group A and those in group F were treated with only distilled water. The rats in Group G were normal rats without wound treated with sildenafil citrate as in Group A. Data collected were analysed using SPSS version 20. Results: The results indicated that sildenafil causes a nonsignificant (P greater than 0.05) decrease in the blood glucose of diabetic rats, a significant (P less than 0.05) increase in the leucocyte count and a significant decrease (p less than 0.05) in the rate of percentage decrease in body weight. Conclusion: Sildenafil may have the potential of reducing the rate of body weight loss in diabetic rats (with or without wound) receiving insulin treatmenthttps://kjmsmedicaljournal.com/wp-content/uploads/2019/09/2_-Ngulde-SI_et-al_KJMSvol10n1.pdfsildenafildiabetic ratswoundbody weightleucocytesglucose |
| spellingShingle | Ngulde SI Umaru B Mahre MB William A Agbutun PA Midda YH Atela PE Daniel HM Giwa-Imam LN EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS Kanem Journal of Medical Sciences sildenafil diabetic rats wound body weight leucocytes glucose |
| title | EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS |
| title_full | EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS |
| title_fullStr | EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS |
| title_full_unstemmed | EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS |
| title_short | EFFECT OF SILDENAFIL CITRATE ON THE BODY WEIGHT, BLOOD GLUCOSE AND WHITE BLOOD CELL COUNT DURING WOUND HEALING PROCESS IN DIABETIC RATS |
| title_sort | effect of sildenafil citrate on the body weight blood glucose and white blood cell count during wound healing process in diabetic rats |
| topic | sildenafil diabetic rats wound body weight leucocytes glucose |
| url | https://kjmsmedicaljournal.com/wp-content/uploads/2019/09/2_-Ngulde-SI_et-al_KJMSvol10n1.pdf |
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