Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations
Pilocytic astrocytoma (PA) is a grade I glial neoplasm arising mainly in the cerebellum of children. Herein, the authors report a case of PA in a 21 year-old male patient, who presented headache, vomiting and delayed pubertal development. Serum level of cortisol and testosterone corresponded to 32.8...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Patologia Clínica
2013-04-01
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| Series: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200011&lng=en&tlng=en |
| _version_ | 1818621604081434624 |
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| author | Eduardo Cambruzzi Karla Lais Pêgas Luciano Carvalho Silveira |
| author_facet | Eduardo Cambruzzi Karla Lais Pêgas Luciano Carvalho Silveira |
| author_sort | Eduardo Cambruzzi |
| collection | DOAJ |
| description | Pilocytic astrocytoma (PA) is a grade I glial neoplasm arising mainly in the cerebellum of children. Herein, the authors report a case of PA in a 21 year-old male patient, who presented headache, vomiting and delayed pubertal development. Serum level of cortisol and testosterone corresponded to 32.8 ug/dl and 0.19 ng/ml, respectively. The computed tomography/magnetic resonance (CT/RM) imaging showed an expansive process compromising suprasellar/hypothalamic region and determining hydrocephalus. The patient underwent resection of the process. Histological evaluation revealed a glial neoplasm constituted by loose glial tissue, small microcysts, areas of dense piloid tissue and Rosenthal fibers. The neoplastic cells were immunoreactive for glial fibrillary acidic protein (GFAP) and negative for chromogranin and synaptophysin. The diagnosis of PA was then established. |
| first_indexed | 2024-12-16T18:11:55Z |
| format | Article |
| id | doaj.art-7c30b5cdbf644382a6e1a15ddbbe93e6 |
| institution | Directory Open Access Journal |
| issn | 1678-4774 |
| language | English |
| last_indexed | 2024-12-16T18:11:55Z |
| publishDate | 2013-04-01 |
| publisher | Sociedade Brasileira de Patologia Clínica |
| record_format | Article |
| series | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| spelling | doaj.art-7c30b5cdbf644382a6e1a15ddbbe93e62022-12-21T22:21:45ZengSociedade Brasileira de Patologia ClínicaJornal Brasileiro de Patologia e Medicina Laboratorial1678-47742013-04-0149213914210.1590/S1676-24442013000200011S1676-24442013000200011Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestationsEduardo Cambruzzi0Karla Lais Pêgas1Luciano Carvalho Silveira2Universidade Luterana do BrasilSanta Casa de Misericórdia de Porto AlegreHospital Cristo RedentorPilocytic astrocytoma (PA) is a grade I glial neoplasm arising mainly in the cerebellum of children. Herein, the authors report a case of PA in a 21 year-old male patient, who presented headache, vomiting and delayed pubertal development. Serum level of cortisol and testosterone corresponded to 32.8 ug/dl and 0.19 ng/ml, respectively. The computed tomography/magnetic resonance (CT/RM) imaging showed an expansive process compromising suprasellar/hypothalamic region and determining hydrocephalus. The patient underwent resection of the process. Histological evaluation revealed a glial neoplasm constituted by loose glial tissue, small microcysts, areas of dense piloid tissue and Rosenthal fibers. The neoplastic cells were immunoreactive for glial fibrillary acidic protein (GFAP) and negative for chromogranin and synaptophysin. The diagnosis of PA was then established.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200011&lng=en&tlng=enastrocitoma pilocíticoneoplasias do sistema nervoso centralpatologianeoplasias encefálicasdoenças do sistema endócrino |
| spellingShingle | Eduardo Cambruzzi Karla Lais Pêgas Luciano Carvalho Silveira Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations Jornal Brasileiro de Patologia e Medicina Laboratorial astrocitoma pilocítico neoplasias do sistema nervoso central patologia neoplasias encefálicas doenças do sistema endócrino |
| title | Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations |
| title_full | Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations |
| title_fullStr | Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations |
| title_full_unstemmed | Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations |
| title_short | Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations |
| title_sort | pilocytic astrocytoma of sellar suprasellar region determining endocrine manifestations |
| topic | astrocitoma pilocítico neoplasias do sistema nervoso central patologia neoplasias encefálicas doenças do sistema endócrino |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442013000200011&lng=en&tlng=en |
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