Altered resting-state neural networks in children and adolescents with functional neurological disorder
Objectives: Previous studies with adults suggest that aberrant communication between neural networks underpins functional neurological disorder (FND). The current study adopts a data-driven approach to investigate the extent that functional resting-state networks are disrupted in a pediatric mixed-F...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222001759 |
| _version_ | 1811315782470074368 |
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| author | Sabina Rai Sheryl Foster Kristi R. Griffiths Isabella A. Breukelaar Kasia Kozlowska Mayuresh S. Korgaonkar |
| author_facet | Sabina Rai Sheryl Foster Kristi R. Griffiths Isabella A. Breukelaar Kasia Kozlowska Mayuresh S. Korgaonkar |
| author_sort | Sabina Rai |
| collection | DOAJ |
| description | Objectives: Previous studies with adults suggest that aberrant communication between neural networks underpins functional neurological disorder (FND). The current study adopts a data-driven approach to investigate the extent that functional resting-state networks are disrupted in a pediatric mixed-FND cohort. Methods: 31 children with mixed FND and 33 age- and sex-matched healthy controls completed resting-state fMRI scans. Whole-brain independent component analysis (pFWE < 0.05) was then used to identify group differences in resting-state connectivity. Self-report measures included the Depression, Anxiety and Stress Scale (DASS-21) and Early Life Stress Questionnaire (ELSQ). Resting-state heart rate (HR) and cortisol-awakening response (CAR) were available in a subset. Results: Children with FND showed wide-ranging connectivity changes in eight independent components corresponding to eight resting-state neural networks: language networks (IC6 and IC1), visual network, frontoparietal network, salience network, dorsal attention network, cerebellar network, and sensorimotor network. Children whose clinical presentation included functional seizures (vs children with other FND symptoms) showed greater connectivity decreases in the frontoparietal and dorsal attentional networks. Subjective distress (total DASS score), autonomic arousal (indexed by HR), and HPA dysregulation (attenuated/reversed CAR) contributed to changes in neural network connectivity. Children with FND (vs controls) reported more subjective distress (total DASS score) and more adverse childhood experiences (ACEs) across their lifespan. Conclusions: Children with FND demonstrate changes in resting-state connectivity. Identified network alterations underpin a broad range of functions typically disrupted in children with FND. This study complements the adult literature by suggesting that FND in children and adolescents emerges in the context of their lived experience and that it reflects aberrant communication across neural networks. |
| first_indexed | 2024-04-13T11:36:18Z |
| format | Article |
| id | doaj.art-7c3174ad32194fb182b10a26fb11619d |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T11:36:18Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-7c3174ad32194fb182b10a26fb11619d2022-12-22T02:48:26ZengElsevierNeuroImage: Clinical2213-15822022-01-0135103110Altered resting-state neural networks in children and adolescents with functional neurological disorderSabina Rai0Sheryl Foster1Kristi R. Griffiths2Isabella A. Breukelaar3Kasia Kozlowska4Mayuresh S. Korgaonkar5Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, Australia; Psychiatry, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaSchool of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Department of Radiology, Westmead Hospital, Westmead, New South Wales, AustraliaBrain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, AustraliaBrain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, Australia; School of Psychology, University of New South Wales, Sydney, AustraliaBrain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, Australia; The Children’s Hospital at Westmead, Sydney Children’s Hospital Network, Sydney, Australia; Child and Adolescent Health, Children’s Hospital Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Corresponding author at: Psychological Medicine, The Children’s Hospital at Westmead, Corner Hawkesbury Rd and Hainsworth St, Westmead, NSW 2145, Australia.Brain Dynamics Centre, Westmead Institute for Medical Research, The University of Sydney, Westmead, Sydney, Australia; Psychiatry, Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaObjectives: Previous studies with adults suggest that aberrant communication between neural networks underpins functional neurological disorder (FND). The current study adopts a data-driven approach to investigate the extent that functional resting-state networks are disrupted in a pediatric mixed-FND cohort. Methods: 31 children with mixed FND and 33 age- and sex-matched healthy controls completed resting-state fMRI scans. Whole-brain independent component analysis (pFWE < 0.05) was then used to identify group differences in resting-state connectivity. Self-report measures included the Depression, Anxiety and Stress Scale (DASS-21) and Early Life Stress Questionnaire (ELSQ). Resting-state heart rate (HR) and cortisol-awakening response (CAR) were available in a subset. Results: Children with FND showed wide-ranging connectivity changes in eight independent components corresponding to eight resting-state neural networks: language networks (IC6 and IC1), visual network, frontoparietal network, salience network, dorsal attention network, cerebellar network, and sensorimotor network. Children whose clinical presentation included functional seizures (vs children with other FND symptoms) showed greater connectivity decreases in the frontoparietal and dorsal attentional networks. Subjective distress (total DASS score), autonomic arousal (indexed by HR), and HPA dysregulation (attenuated/reversed CAR) contributed to changes in neural network connectivity. Children with FND (vs controls) reported more subjective distress (total DASS score) and more adverse childhood experiences (ACEs) across their lifespan. Conclusions: Children with FND demonstrate changes in resting-state connectivity. Identified network alterations underpin a broad range of functions typically disrupted in children with FND. This study complements the adult literature by suggesting that FND in children and adolescents emerges in the context of their lived experience and that it reflects aberrant communication across neural networks.http://www.sciencedirect.com/science/article/pii/S2213158222001759Resting-state fMRIFunctional neurological disorder (FND)Conversion disorderFunctional seizuresChildren and adolescentsAdverse childhood experiences |
| spellingShingle | Sabina Rai Sheryl Foster Kristi R. Griffiths Isabella A. Breukelaar Kasia Kozlowska Mayuresh S. Korgaonkar Altered resting-state neural networks in children and adolescents with functional neurological disorder NeuroImage: Clinical Resting-state fMRI Functional neurological disorder (FND) Conversion disorder Functional seizures Children and adolescents Adverse childhood experiences |
| title | Altered resting-state neural networks in children and adolescents with functional neurological disorder |
| title_full | Altered resting-state neural networks in children and adolescents with functional neurological disorder |
| title_fullStr | Altered resting-state neural networks in children and adolescents with functional neurological disorder |
| title_full_unstemmed | Altered resting-state neural networks in children and adolescents with functional neurological disorder |
| title_short | Altered resting-state neural networks in children and adolescents with functional neurological disorder |
| title_sort | altered resting state neural networks in children and adolescents with functional neurological disorder |
| topic | Resting-state fMRI Functional neurological disorder (FND) Conversion disorder Functional seizures Children and adolescents Adverse childhood experiences |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222001759 |
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