Absolute Structure Determination and Kv1.5 Ion Channel Inhibition Activities of New Debromoaplysiatoxin Analogues

Absolute Structure Determination and Kv1.5 Ion Channel Inhibition Activities of New Debromoaplysiatoxin Analogues

Potassium channel Kv1.5 has been considered a key target for new treatments of atrial tachyarrhythmias, with few side effects. Four new debromoaplysiatoxin analogues with a 6/6/12 fused ring system were isolated from marine cyanobacterium <i>Lyngbya</i> sp. Their planar structures were e...

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Bibliographic Details
Main Authors: Sicheng Shen, Weiping Wang, Zijun Chen, Huihui Zhang, Yuchun Yang, Xiaoliang Wang, Peng Fu, Bingnan Han
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Marine Drugs
Subjects:
marine cyanobacterium
debromoaplysiatoxin analogues
absolute configuration
Kv1.5 inhibitory activity
brine shrimp toxicity
Online Access:https://www.mdpi.com/1660-3397/19/11/630

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