Sirtuins as regulators of the yeast metabolic network
There is growing evidence that the metabolic network is an integral regulator of cellularphysiology. Dynamic changes in metabolite concentrations, metabolic flux, or networktopology act as reporters of biological or environmental signals, and are required for the cellto trigger an appropriate biolog...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00032/full |
| _version_ | 1828485465318096896 |
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| author | Markus eRalser Markus eRalser Steve eMichel Michael eBreitenbach |
| author_facet | Markus eRalser Markus eRalser Steve eMichel Michael eBreitenbach |
| author_sort | Markus eRalser |
| collection | DOAJ |
| description | There is growing evidence that the metabolic network is an integral regulator of cellularphysiology. Dynamic changes in metabolite concentrations, metabolic flux, or networktopology act as reporters of biological or environmental signals, and are required for the cellto trigger an appropriate biological reaction. Changes in the metabolic network are recognizedby specific sensory macromolecules and translated into a transcriptional or translationalresponse. The protein family of sirtuins, discovered more than 30 years ago as regulators ofsilent chromatin, seems to fulfill the role of a metabolic sensor during aging and conditions ofcaloric restriction. NAD+/NADH interconverting metabolic enzymes glyceraldehyde-3-phosphate dehydrogenase and alcohol dehydrogenase, as well as enzymes involved inNAD(H), synthesis provide or deprive NAD+ in close proximity to Sir2. This influence sirtuinactivity, and facilitates a dynamic response of the metabolic network to changes inmetabolism with effects on physiology and aging. The molecular network downstream Sir2,however, is complex. In just two orders, Sir2’s metabolism-related interactions span half ofthe yeast proteome, and are connected with virtually every physiological process. Thus,although it is fundamental to analyze single molecular mechanisms, it is at the same timecrucial to consider this genome-scale complexity when correlating single molecular eventswith phenotypes such as aging, cell growth, or stress resistance. |
| first_indexed | 2024-12-11T09:15:04Z |
| format | Article |
| id | doaj.art-7c32b8396f0346acb348c9ae0c427cce |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-11T09:15:04Z |
| publishDate | 2012-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-7c32b8396f0346acb348c9ae0c427cce2022-12-22T01:13:24ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122012-03-01310.3389/fphar.2012.0003220950Sirtuins as regulators of the yeast metabolic networkMarkus eRalser0Markus eRalser1Steve eMichel2Michael eBreitenbach3University of CambridgeMax Planck Institute for Molecular GeneticsMax Planck Institute for Molecular GeneticsUniversity of SalzburgThere is growing evidence that the metabolic network is an integral regulator of cellularphysiology. Dynamic changes in metabolite concentrations, metabolic flux, or networktopology act as reporters of biological or environmental signals, and are required for the cellto trigger an appropriate biological reaction. Changes in the metabolic network are recognizedby specific sensory macromolecules and translated into a transcriptional or translationalresponse. The protein family of sirtuins, discovered more than 30 years ago as regulators ofsilent chromatin, seems to fulfill the role of a metabolic sensor during aging and conditions ofcaloric restriction. NAD+/NADH interconverting metabolic enzymes glyceraldehyde-3-phosphate dehydrogenase and alcohol dehydrogenase, as well as enzymes involved inNAD(H), synthesis provide or deprive NAD+ in close proximity to Sir2. This influence sirtuinactivity, and facilitates a dynamic response of the metabolic network to changes inmetabolism with effects on physiology and aging. The molecular network downstream Sir2,however, is complex. In just two orders, Sir2’s metabolism-related interactions span half ofthe yeast proteome, and are connected with virtually every physiological process. Thus,although it is fundamental to analyze single molecular mechanisms, it is at the same timecrucial to consider this genome-scale complexity when correlating single molecular eventswith phenotypes such as aging, cell growth, or stress resistance.http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00032/fullAgingCaloric RestrictionGlycolysisPentose Phosphate PathwaySirtuinsmetabolic network |
| spellingShingle | Markus eRalser Markus eRalser Steve eMichel Michael eBreitenbach Sirtuins as regulators of the yeast metabolic network Frontiers in Pharmacology Aging Caloric Restriction Glycolysis Pentose Phosphate Pathway Sirtuins metabolic network |
| title | Sirtuins as regulators of the yeast metabolic network |
| title_full | Sirtuins as regulators of the yeast metabolic network |
| title_fullStr | Sirtuins as regulators of the yeast metabolic network |
| title_full_unstemmed | Sirtuins as regulators of the yeast metabolic network |
| title_short | Sirtuins as regulators of the yeast metabolic network |
| title_sort | sirtuins as regulators of the yeast metabolic network |
| topic | Aging Caloric Restriction Glycolysis Pentose Phosphate Pathway Sirtuins metabolic network |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00032/full |
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