Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content

Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content

Abstract Background Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for diagnosis and prognosis of cancer. Molecular profiling of ctDNA is often...

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Bibliographic Details
Main Authors: Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson, Lachlan J. M. Coin
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Cancer
Subjects:
Cell-free DNA
Cell-free tumour DNA
Somatic mutations
Mutational signatures
Online Access:https://doi.org/10.1186/s12885-021-09160-1

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