Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease i...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/3221 |
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| author | Oxana Semyachkina-Glushkovskaya Ivan Fedosov Thomas Penzel Dongyu Li Tingting Yu Valeria Telnova Elmira Kaybeleva Elena Saranceva Andrey Terskov Alexander Khorovodov Inna Blokhina Jürgen Kurths Dan Zhu |
| author_facet | Oxana Semyachkina-Glushkovskaya Ivan Fedosov Thomas Penzel Dongyu Li Tingting Yu Valeria Telnova Elmira Kaybeleva Elena Saranceva Andrey Terskov Alexander Khorovodov Inna Blokhina Jürgen Kurths Dan Zhu |
| author_sort | Oxana Semyachkina-Glushkovskaya |
| collection | DOAJ |
| description | Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. |
| first_indexed | 2024-03-11T08:44:04Z |
| format | Article |
| id | doaj.art-7c34db09993947d1b5a1488ff3786c0f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:44:04Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7c34db09993947d1b5a1488ff3786c0f2023-11-16T20:56:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244322110.3390/ijms24043221Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain DiseasesOxana Semyachkina-Glushkovskaya0Ivan Fedosov1Thomas Penzel2Dongyu Li3Tingting Yu4Valeria Telnova5Elmira Kaybeleva6Elena Saranceva7Andrey Terskov8Alexander Khorovodov9Inna Blokhina10Jürgen Kurths11Dan Zhu12Institute of Physics, Humboldt University, Newtonstrasse 15, 12489 Berlin, GermanyDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaOptics Valley Laboratory, Huazhong University of Science and Technology, Wuhan 430074, ChinaOptics Valley Laboratory, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaDepartment of Biology, Saratov State University, Astrakhanskaya 82, 410012 Saratov, RussiaInstitute of Physics, Humboldt University, Newtonstrasse 15, 12489 Berlin, GermanyOptics Valley Laboratory, Huazhong University of Science and Technology, Wuhan 430074, ChinaEmerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases.https://www.mdpi.com/1422-0067/24/4/3221brain diseasesmeningeal lymphatic vesselsphotobiomodulation |
| spellingShingle | Oxana Semyachkina-Glushkovskaya Ivan Fedosov Thomas Penzel Dongyu Li Tingting Yu Valeria Telnova Elmira Kaybeleva Elena Saranceva Andrey Terskov Alexander Khorovodov Inna Blokhina Jürgen Kurths Dan Zhu Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases International Journal of Molecular Sciences brain diseases meningeal lymphatic vessels photobiomodulation |
| title | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
| title_full | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
| title_fullStr | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
| title_full_unstemmed | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
| title_short | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
| title_sort | brain waste removal system and sleep photobiomodulation as an innovative strategy for night therapy of brain diseases |
| topic | brain diseases meningeal lymphatic vessels photobiomodulation |
| url | https://www.mdpi.com/1422-0067/24/4/3221 |
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