Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury
Cardiovascular disease (CVD) continues to be the leading cause of death in the world. Increased inflammation and an enhanced thrombotic milieu represent two major complications of CVD, which can culminate into an ischemic event. Treatment for these life-threatening complications remains reperfusion...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/19/4/1211 |
| _version_ | 1811193486577238016 |
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| author | Junaid Ansari Gaganpreet Kaur Felicity N. E. Gavins |
| author_facet | Junaid Ansari Gaganpreet Kaur Felicity N. E. Gavins |
| author_sort | Junaid Ansari |
| collection | DOAJ |
| description | Cardiovascular disease (CVD) continues to be the leading cause of death in the world. Increased inflammation and an enhanced thrombotic milieu represent two major complications of CVD, which can culminate into an ischemic event. Treatment for these life-threatening complications remains reperfusion and restoration of blood flow. However, reperfusion strategies may result in ischemia–reperfusion injury (I/RI) secondary to various cardiovascular pathologies, including myocardial infarction and stroke, by furthering the inflammatory and thrombotic responses and delivering inflammatory mediators to the affected tissue. Annexin A1 (AnxA1) and its mimetic peptides are endogenous anti-inflammatory and pro-resolving mediators, known to have significant effects in resolving inflammation in a variety of disease models. Mounting evidence suggests that AnxA1, which interacts with the formyl peptide receptor (FPR) family, may have a significant role in mitigating I/RI associated complications. In this review article, we focus on how AnxA1 plays a protective role in the I/R based vascular pathologies. |
| first_indexed | 2024-04-12T00:10:37Z |
| format | Article |
| id | doaj.art-7c363bdb11a642df96b2b729b2a289ab |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T00:10:37Z |
| publishDate | 2018-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7c363bdb11a642df96b2b729b2a289ab2022-12-22T03:55:59ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-04-01194121110.3390/ijms19041211ijms19041211Therapeutic Potential of Annexin A1 in Ischemia Reperfusion InjuryJunaid Ansari0Gaganpreet Kaur1Felicity N. E. Gavins2Department of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71130, USADepartment of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71130, USADepartment of Molecular & Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA 71130, USACardiovascular disease (CVD) continues to be the leading cause of death in the world. Increased inflammation and an enhanced thrombotic milieu represent two major complications of CVD, which can culminate into an ischemic event. Treatment for these life-threatening complications remains reperfusion and restoration of blood flow. However, reperfusion strategies may result in ischemia–reperfusion injury (I/RI) secondary to various cardiovascular pathologies, including myocardial infarction and stroke, by furthering the inflammatory and thrombotic responses and delivering inflammatory mediators to the affected tissue. Annexin A1 (AnxA1) and its mimetic peptides are endogenous anti-inflammatory and pro-resolving mediators, known to have significant effects in resolving inflammation in a variety of disease models. Mounting evidence suggests that AnxA1, which interacts with the formyl peptide receptor (FPR) family, may have a significant role in mitigating I/RI associated complications. In this review article, we focus on how AnxA1 plays a protective role in the I/R based vascular pathologies.http://www.mdpi.com/1422-0067/19/4/1211ischemia–reperfusion injuryAnnexin A1formyl peptide receptorsischemic stroke |
| spellingShingle | Junaid Ansari Gaganpreet Kaur Felicity N. E. Gavins Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury International Journal of Molecular Sciences ischemia–reperfusion injury Annexin A1 formyl peptide receptors ischemic stroke |
| title | Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury |
| title_full | Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury |
| title_fullStr | Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury |
| title_full_unstemmed | Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury |
| title_short | Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury |
| title_sort | therapeutic potential of annexin a1 in ischemia reperfusion injury |
| topic | ischemia–reperfusion injury Annexin A1 formyl peptide receptors ischemic stroke |
| url | http://www.mdpi.com/1422-0067/19/4/1211 |
| work_keys_str_mv | AT junaidansari therapeuticpotentialofannexina1inischemiareperfusioninjury AT gaganpreetkaur therapeuticpotentialofannexina1inischemiareperfusioninjury AT felicitynegavins therapeuticpotentialofannexina1inischemiareperfusioninjury |