PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS
The article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in...
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2012-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/893 |
| _version_ | 1826853649216700416 |
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| author | A. A. Koshkina V. V. Novitskij O. I. Urazova I. E. Esimova R. R. Hasanova |
| author_facet | A. A. Koshkina V. V. Novitskij O. I. Urazova I. E. Esimova R. R. Hasanova |
| author_sort | A. A. Koshkina |
| collection | DOAJ |
| description | The article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in the total amount of CD3-positive cells and suppression of IL-2- secretion during CD3/CD28-induction of lymphocytes, which was most expressed in a disseminated form of drug-resistant TB. We also demonstrated the reduction in the percentage value of CD3+CD28+IL-2+ and CD3+CD28+IL-2- cells in patients with pulmonary TB against the background of the increase in the percentage value of CD3+CD28-IL-2-. Besides, it was also shown that the detected changes are unidirectional, don't depend on a clinical form of TB and are maximally manifested in patients with a drug resistant variant of the TB process. |
| first_indexed | 2024-03-08T12:23:10Z |
| format | Article |
| id | doaj.art-7c363fae98314423a12311264c1119a4 |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:30:32Z |
| publishDate | 2012-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-7c363fae98314423a12311264c1119a42025-01-27T16:48:37ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962012-05-0103(2)9295839PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSISA. A. Koshkina0V. V. Novitskij1O. I. Urazova2I. E. Esimova3R. R. Hasanova4Siberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityThe article presents the results of the research of CD3/CD28-induced production of interleukin-2 by blood lymphocytes in vitro as well as subpopulation composition of peripheral blood T-lymphocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. We detected the decrease in the total amount of CD3-positive cells and suppression of IL-2- secretion during CD3/CD28-induction of lymphocytes, which was most expressed in a disseminated form of drug-resistant TB. We also demonstrated the reduction in the percentage value of CD3+CD28+IL-2+ and CD3+CD28+IL-2- cells in patients with pulmonary TB against the background of the increase in the percentage value of CD3+CD28-IL-2-. Besides, it was also shown that the detected changes are unidirectional, don't depend on a clinical form of TB and are maximally manifested in patients with a drug resistant variant of the TB process.https://www.actabiomedica.ru/jour/article/view/893pulmonary tuberculosist-lymphocytesinterleukin-2intercellular cooperation |
| spellingShingle | A. A. Koshkina V. V. Novitskij O. I. Urazova I. E. Esimova R. R. Hasanova PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS Acta Biomedica Scientifica pulmonary tuberculosis t-lymphocytes interleukin-2 intercellular cooperation |
| title | PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full | PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_fullStr | PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_full_unstemmed | PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_short | PECULIARITIES OF CD3/CD28-INDUCED SECRETION OF INTERLEUKIN-2 AND SUBPOPULATION COMPOSITION OF T-LYMPHOCYTES IN PATIENTS WITH PULMONARY TUBERCULOSIS |
| title_sort | peculiarities of cd3 cd28 induced secretion of interleukin 2 and subpopulation composition of t lymphocytes in patients with pulmonary tuberculosis |
| topic | pulmonary tuberculosis t-lymphocytes interleukin-2 intercellular cooperation |
| url | https://www.actabiomedica.ru/jour/article/view/893 |
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