THE ROLE OF INDY IN METABOLIC REGULATION
Reduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc13a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2013-03-01
|
| Series: | Computational and Structural Biotechnology Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S200103701460129X |
| _version_ | 1818024082238603264 |
|---|---|
| author | Diana M Willmes Andreas L Birkenfeld |
| author_facet | Diana M Willmes Andreas L Birkenfeld |
| author_sort | Diana M Willmes |
| collection | DOAJ |
| description | Reduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc13a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ß-oxidation. This review will provide an overview on different mammalian SLC13 family members with a focus on mINDY (SLC13A5) in glucose and energy metabolism and will highlight the role of mINDY as a putative therapeutic target for the treatment of obesity, non-alcoholic fatty liver disease and type 2 diabetes. |
| first_indexed | 2024-12-10T03:54:33Z |
| format | Article |
| id | doaj.art-7c384f2def2c4562a5d78fdedd2f9f8e |
| institution | Directory Open Access Journal |
| issn | 2001-0370 |
| language | English |
| last_indexed | 2024-12-10T03:54:33Z |
| publishDate | 2013-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Computational and Structural Biotechnology Journal |
| spelling | doaj.art-7c384f2def2c4562a5d78fdedd2f9f8e2022-12-22T02:03:09ZengElsevierComputational and Structural Biotechnology Journal2001-03702013-03-016710.5936/csbj.201303020THE ROLE OF INDY IN METABOLIC REGULATIONDiana M Willmes0Andreas L Birkenfeld1Department of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research, Charité – University School of Medicine, Berlin, GermanyDepartment of Endocrinology, Diabetes and Nutrition, Center for Cardiovascular Research, Charité – University School of Medicine, Berlin, GermanyReduced expression of the Indy (I'm Not Dead Yet) gene in D. melanogaster and C. elegans extends longevity. Indy and its mammalian homolog mINDY (Slc13a5, NaCT) are transporters of TCA cycle intermediates, mainly handling the uptake of citrate via the plasma membrane into the cytosol. Deletion of mINDY in mice leads to significant metabolic changes akin to caloric restriction, likely caused by reducing the effects of mINDY-imported citrate on fatty acid and cholesterol synthesis, glucose metabolism and ß-oxidation. This review will provide an overview on different mammalian SLC13 family members with a focus on mINDY (SLC13A5) in glucose and energy metabolism and will highlight the role of mINDY as a putative therapeutic target for the treatment of obesity, non-alcoholic fatty liver disease and type 2 diabetes.http://www.sciencedirect.com/science/article/pii/S200103701460129XINDYcitrateinsulin resistancediabetesobesitylongevity |
| spellingShingle | Diana M Willmes Andreas L Birkenfeld THE ROLE OF INDY IN METABOLIC REGULATION Computational and Structural Biotechnology Journal INDY citrate insulin resistance diabetes obesity longevity |
| title | THE ROLE OF INDY IN METABOLIC REGULATION |
| title_full | THE ROLE OF INDY IN METABOLIC REGULATION |
| title_fullStr | THE ROLE OF INDY IN METABOLIC REGULATION |
| title_full_unstemmed | THE ROLE OF INDY IN METABOLIC REGULATION |
| title_short | THE ROLE OF INDY IN METABOLIC REGULATION |
| title_sort | role of indy in metabolic regulation |
| topic | INDY citrate insulin resistance diabetes obesity longevity |
| url | http://www.sciencedirect.com/science/article/pii/S200103701460129X |
| work_keys_str_mv | AT dianamwillmes theroleofindyinmetabolicregulation AT andreaslbirkenfeld theroleofindyinmetabolicregulation AT dianamwillmes roleofindyinmetabolicregulation AT andreaslbirkenfeld roleofindyinmetabolicregulation |