Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration
Objectives: The aim of the review is to present the currently applied tissue regeneration through stem cells technology in regenerative endodontics. This review also summarises the various preclinical models used for the evaluation of stem cell-based therapies, their limitations, recent advances an...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2023-02-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/9066 |
| _version_ | 1797820943301607424 |
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| author | Syeda Abeerah Tanveer Zainab Haji Robia Ghafoor |
| author_facet | Syeda Abeerah Tanveer Zainab Haji Robia Ghafoor |
| author_sort | Syeda Abeerah Tanveer |
| collection | DOAJ |
| description |
Objectives: The aim of the review is to present the currently applied tissue regeneration through stem cells technology in regenerative endodontics. This review also summarises the various preclinical models used for the evaluation of stem cell-based therapies, their limitations, recent advances and challenges related to clinical applications of human stem cells.
Methodology: A literature survey from 2010 to August 2022 was carried out in various electronic databases to identify the articles required for review on Pulp Regeneration through Stem Cells Technology. MeSH terms/keywords such as “Pulp regeneration,” “Pulp Revascularization,” “Pulp revitalization,” “Regenerative Endodontics” were used to search in the electronic databases comprised of PubMed database, SCOPUS, COCHRANRE library, EMBASE, CINAHL, ICTRP, Science Direct and a manual search was also done using the cross references and textbooks.
Results: The searches revealed 299 articles. After reading the full text articles and applying the inclusion and exclusion criteria 15 articles were selected for the review fulfilling the criteria of the study.
Conclusion: Currently in regenerative endodontics, there is a broad consent that the final tissue acquired is more likely to bone-like tissue mixed with connective tissue rather than the pulp-dentin complex. Moreover, re-innervation from sensory axons in regenerated tissue, is still to date, difficult to achieve.
Keywords: Endodontics, Biocompatible, Pulp, Stem Cells, Tissue, Dentin, Axons
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| first_indexed | 2024-03-13T09:45:36Z |
| format | Article |
| id | doaj.art-7c389990fbd5488d95285af6ccc3ea38 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:45:36Z |
| publishDate | 2023-02-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-7c389990fbd5488d95285af6ccc3ea382023-05-25T04:20:52ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-02-0173210.47391/JPMA.AKUS-07Clinical applications and novel approaches in stem cell: an insight to dental pulp regenerationSyeda Abeerah Tanveer0Zainab Haji1Robia Ghafoor2Department of Surgery, Operative Dentistry and Endodontics, Aga Khan University Hospital, Karachi, PakistanDepartment of Surgery, Operative Dentistry and Endodontics, Aga Khan University Hospital, Karachi, Pakistan Department of Surgery, Operative Dentistry and Endodontics, Aga Khan University Hospital, Karachi, Pakistan Objectives: The aim of the review is to present the currently applied tissue regeneration through stem cells technology in regenerative endodontics. This review also summarises the various preclinical models used for the evaluation of stem cell-based therapies, their limitations, recent advances and challenges related to clinical applications of human stem cells. Methodology: A literature survey from 2010 to August 2022 was carried out in various electronic databases to identify the articles required for review on Pulp Regeneration through Stem Cells Technology. MeSH terms/keywords such as “Pulp regeneration,” “Pulp Revascularization,” “Pulp revitalization,” “Regenerative Endodontics” were used to search in the electronic databases comprised of PubMed database, SCOPUS, COCHRANRE library, EMBASE, CINAHL, ICTRP, Science Direct and a manual search was also done using the cross references and textbooks. Results: The searches revealed 299 articles. After reading the full text articles and applying the inclusion and exclusion criteria 15 articles were selected for the review fulfilling the criteria of the study. Conclusion: Currently in regenerative endodontics, there is a broad consent that the final tissue acquired is more likely to bone-like tissue mixed with connective tissue rather than the pulp-dentin complex. Moreover, re-innervation from sensory axons in regenerated tissue, is still to date, difficult to achieve. Keywords: Endodontics, Biocompatible, Pulp, Stem Cells, Tissue, Dentin, Axons https://www.ojs.jpma.org.pk/index.php/public_html/article/view/9066 |
| spellingShingle | Syeda Abeerah Tanveer Zainab Haji Robia Ghafoor Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration Journal of the Pakistan Medical Association |
| title | Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration |
| title_full | Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration |
| title_fullStr | Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration |
| title_full_unstemmed | Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration |
| title_short | Clinical applications and novel approaches in stem cell: an insight to dental pulp regeneration |
| title_sort | clinical applications and novel approaches in stem cell an insight to dental pulp regeneration |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/9066 |
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