Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat
Abstract Background Tributyltin, a well-known endocrine disruptor, is widely used in agriculture and industry. Previous studies have shown that tributyltin could cause deleterious effects on bone health by impairing the adipo-osteogenic balance in bone marrow. Methods To investigate further the effe...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-05-01
|
| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-021-04298-2 |
| _version_ | 1818572409245007872 |
|---|---|
| author | Mingjun Li Dong Cheng Hui Li Wenhuan Yao Dongmei Guo Shu’e Wang Jiliang Si |
| author_facet | Mingjun Li Dong Cheng Hui Li Wenhuan Yao Dongmei Guo Shu’e Wang Jiliang Si |
| author_sort | Mingjun Li |
| collection | DOAJ |
| description | Abstract Background Tributyltin, a well-known endocrine disruptor, is widely used in agriculture and industry. Previous studies have shown that tributyltin could cause deleterious effects on bone health by impairing the adipo-osteogenic balance in bone marrow. Methods To investigate further the effects of tributyltin on bone, weaned male SD rats were treated with tributyltin (0.5, 5 or 50 μg·kg− 1) or corn oil by gavage once every 3 days for 60 days in this study. Then, we analyzed the effects of tributyltin on geometry, the polar moment of inertia, mineral content, relative abundances of mRNA from representative genes related to adipogenesis and osteogenesis, serum calcium ion and inorganic phosphate levels. Results Micro-computed tomography analysis revealed that treatment with 50 μg·kg− 1 tributyltin caused an obvious decrease in femoral cortical cross sectional area, marrow area, periosteal circumference and derived polar moment of inertia in rats. However, other test results showed that exposure to tributyltin resulted in no significant changes in the expression of genes detected, femoral cancellous architecture, ash content, as well as serum calcium ion and inorganic phosphate levels. Conclusions Exposure to a low dose of tributyltin from the prepubertal to adult stage produced adverse effects on skeletal architecture and strength. |
| first_indexed | 2024-12-14T18:56:41Z |
| format | Article |
| id | doaj.art-7c399fb71ef442189339c1edb9e4fb4c |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-14T18:56:41Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-7c399fb71ef442189339c1edb9e4fb4c2022-12-21T22:51:05ZengBMCBMC Musculoskeletal Disorders1471-24742021-05-012211910.1186/s12891-021-04298-2Tributyltin perturbs femoral cortical architecture and polar moment of inertia in ratMingjun Li0Dong Cheng1Hui Li2Wenhuan Yao3Dongmei Guo4Shu’e Wang5Jiliang Si6Department of Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Toxicology, Shandong Center for Disease Control and PreventionDepartment of Toxicology, Shandong Center for Disease Control and PreventionDepartment of Toxicology, Shandong Center for Disease Control and PreventionDepartment of Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityDepartment of Environmental Health, School of Public Health, Cheeloo College of Medicine, Shandong UniversityAbstract Background Tributyltin, a well-known endocrine disruptor, is widely used in agriculture and industry. Previous studies have shown that tributyltin could cause deleterious effects on bone health by impairing the adipo-osteogenic balance in bone marrow. Methods To investigate further the effects of tributyltin on bone, weaned male SD rats were treated with tributyltin (0.5, 5 or 50 μg·kg− 1) or corn oil by gavage once every 3 days for 60 days in this study. Then, we analyzed the effects of tributyltin on geometry, the polar moment of inertia, mineral content, relative abundances of mRNA from representative genes related to adipogenesis and osteogenesis, serum calcium ion and inorganic phosphate levels. Results Micro-computed tomography analysis revealed that treatment with 50 μg·kg− 1 tributyltin caused an obvious decrease in femoral cortical cross sectional area, marrow area, periosteal circumference and derived polar moment of inertia in rats. However, other test results showed that exposure to tributyltin resulted in no significant changes in the expression of genes detected, femoral cancellous architecture, ash content, as well as serum calcium ion and inorganic phosphate levels. Conclusions Exposure to a low dose of tributyltin from the prepubertal to adult stage produced adverse effects on skeletal architecture and strength.https://doi.org/10.1186/s12891-021-04298-2TributyltinAdipogenesisOsteogenesisBone geometryMicro-computed tomographyPolar moment of inertia |
| spellingShingle | Mingjun Li Dong Cheng Hui Li Wenhuan Yao Dongmei Guo Shu’e Wang Jiliang Si Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat BMC Musculoskeletal Disorders Tributyltin Adipogenesis Osteogenesis Bone geometry Micro-computed tomography Polar moment of inertia |
| title | Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat |
| title_full | Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat |
| title_fullStr | Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat |
| title_full_unstemmed | Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat |
| title_short | Tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat |
| title_sort | tributyltin perturbs femoral cortical architecture and polar moment of inertia in rat |
| topic | Tributyltin Adipogenesis Osteogenesis Bone geometry Micro-computed tomography Polar moment of inertia |
| url | https://doi.org/10.1186/s12891-021-04298-2 |
| work_keys_str_mv | AT mingjunli tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat AT dongcheng tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat AT huili tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat AT wenhuanyao tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat AT dongmeiguo tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat AT shuewang tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat AT jiliangsi tributyltinperturbsfemoralcorticalarchitectureandpolarmomentofinertiainrat |