Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma
Summary: Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction ant...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-11-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761620300089 |
| _version_ | 1818437656988614656 |
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| author | Smitha Sammith Shetty Mohit Sharma Felipe Paiva Fonseca Pradyumna Jayaram Ankit Singh Tanwar Shama Prasada Kabekkodu Kapaettu Satyamoorthy Raghu Radhakrishnan |
| author_facet | Smitha Sammith Shetty Mohit Sharma Felipe Paiva Fonseca Pradyumna Jayaram Ankit Singh Tanwar Shama Prasada Kabekkodu Kapaettu Satyamoorthy Raghu Radhakrishnan |
| author_sort | Smitha Sammith Shetty |
| collection | DOAJ |
| description | Summary: Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways. |
| first_indexed | 2024-12-14T17:28:09Z |
| format | Article |
| id | doaj.art-7c3a546a52b046e8a293309d0310be9e |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-14T17:28:09Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-7c3a546a52b046e8a293309d0310be9e2022-12-21T22:53:10ZengElsevierJapanese Dental Science Review1882-76162020-11-0156197108Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinomaSmitha Sammith Shetty0Mohit Sharma1Felipe Paiva Fonseca2Pradyumna Jayaram3Ankit Singh Tanwar4Shama Prasada Kabekkodu5Kapaettu Satyamoorthy6Raghu Radhakrishnan7Department of Oral Pathology, Faculty of Dentistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Oral Pathology, Sudha Rustagi College of Dental Sciences and Research, Faridabad 121004, IndiaDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, BrazilDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, IndiaDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, IndiaDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, IndiaDepartment of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, 576104, IndiaDepartment of Oral Pathology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher Education, Manipal 576104, India; Corresponding author.Summary: Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways.http://www.sciencedirect.com/science/article/pii/S1882761620300089Oral submucous fibrosis (OSF)Epithelial-mesenchymal transition (EMT)Oral squamous cell carcinoma (OSCC)Type II EMTSignaling pathways in EMTTranscription factors in EMT |
| spellingShingle | Smitha Sammith Shetty Mohit Sharma Felipe Paiva Fonseca Pradyumna Jayaram Ankit Singh Tanwar Shama Prasada Kabekkodu Kapaettu Satyamoorthy Raghu Radhakrishnan Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma Japanese Dental Science Review Oral submucous fibrosis (OSF) Epithelial-mesenchymal transition (EMT) Oral squamous cell carcinoma (OSCC) Type II EMT Signaling pathways in EMT Transcription factors in EMT |
| title | Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma |
| title_full | Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma |
| title_fullStr | Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma |
| title_full_unstemmed | Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma |
| title_short | Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma |
| title_sort | signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma |
| topic | Oral submucous fibrosis (OSF) Epithelial-mesenchymal transition (EMT) Oral squamous cell carcinoma (OSCC) Type II EMT Signaling pathways in EMT Transcription factors in EMT |
| url | http://www.sciencedirect.com/science/article/pii/S1882761620300089 |
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