Bone/cartilage organoid on-chip: Construction strategy and application
The necessity of disease models for bone/cartilage related disorders is well-recognized, but the barrier between ex-vivo cell culture, animal models and the real human body has been pending for decades. The organoid-on-a-chip technique showed opportunity to revolutionize basic research and drug scre...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-07-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23000166 |
| _version_ | 1797861092645404672 |
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| author | Yan Hu Hao Zhang Sicheng Wang Liehu Cao Fengjin Zhou Yingying Jing Jiacan Su |
| author_facet | Yan Hu Hao Zhang Sicheng Wang Liehu Cao Fengjin Zhou Yingying Jing Jiacan Su |
| author_sort | Yan Hu |
| collection | DOAJ |
| description | The necessity of disease models for bone/cartilage related disorders is well-recognized, but the barrier between ex-vivo cell culture, animal models and the real human body has been pending for decades. The organoid-on-a-chip technique showed opportunity to revolutionize basic research and drug screening for diseases like osteoporosis and arthritis. The bone/cartilage organoid on-chip (BCoC) system is a novel platform of multi-tissue which faithfully emulate the essential elements, biologic functions and pathophysiological response under real circumstances. In this review, we propose the concept of BCoC platform, summarize the basic modules and current efforts to orchestrate them on a single microfluidic system. Current disease models, unsolved problems and future challenging are also discussed, the aim should be a deeper understanding of diseases, and ultimate realization of generic ex-vivo tools for further therapeutic strategies of pathological conditions. |
| first_indexed | 2024-04-09T21:56:29Z |
| format | Article |
| id | doaj.art-7c3d33e2bca9443b9f3d1079aa09a857 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-09T21:56:29Z |
| publishDate | 2023-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-7c3d33e2bca9443b9f3d1079aa09a8572023-03-24T04:23:07ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-07-01252941Bone/cartilage organoid on-chip: Construction strategy and applicationYan Hu0Hao Zhang1Sicheng Wang2Liehu Cao3Fengjin Zhou4Yingying Jing5Jiacan Su6Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; Shaoxing Institute of Technology at Shanghai University, Shaoxing, 312000, ChinaInstitute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, ChinaDepartment of Orthopaedics, Shanghai Zhongye Hospital, Shanghai, 201941, ChinaDepartment of Orthopaedics, Shanghai Baoshan Luodian Hospital, Shanghai, 201908, ChinaDepartment of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China; Corresponding author. Department of Orthopaedics, Honghui Hospital, Xi'an Jiao Tong University, Xi'an, 710000, China.Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; Corresponding author. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China; Department of Orthopaedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China; Musculoskeletal Organoid Research Center, Shanghai University, Shanghai, 200444, China; Corresponding author. Institute of Translational Medicine, Shanghai University, Shanghai, 200444, China.The necessity of disease models for bone/cartilage related disorders is well-recognized, but the barrier between ex-vivo cell culture, animal models and the real human body has been pending for decades. The organoid-on-a-chip technique showed opportunity to revolutionize basic research and drug screening for diseases like osteoporosis and arthritis. The bone/cartilage organoid on-chip (BCoC) system is a novel platform of multi-tissue which faithfully emulate the essential elements, biologic functions and pathophysiological response under real circumstances. In this review, we propose the concept of BCoC platform, summarize the basic modules and current efforts to orchestrate them on a single microfluidic system. Current disease models, unsolved problems and future challenging are also discussed, the aim should be a deeper understanding of diseases, and ultimate realization of generic ex-vivo tools for further therapeutic strategies of pathological conditions.http://www.sciencedirect.com/science/article/pii/S2452199X23000166OrganoidOn-chip platformOsteochondral unitEx-vivo disease model |
| spellingShingle | Yan Hu Hao Zhang Sicheng Wang Liehu Cao Fengjin Zhou Yingying Jing Jiacan Su Bone/cartilage organoid on-chip: Construction strategy and application Bioactive Materials Organoid On-chip platform Osteochondral unit Ex-vivo disease model |
| title | Bone/cartilage organoid on-chip: Construction strategy and application |
| title_full | Bone/cartilage organoid on-chip: Construction strategy and application |
| title_fullStr | Bone/cartilage organoid on-chip: Construction strategy and application |
| title_full_unstemmed | Bone/cartilage organoid on-chip: Construction strategy and application |
| title_short | Bone/cartilage organoid on-chip: Construction strategy and application |
| title_sort | bone cartilage organoid on chip construction strategy and application |
| topic | Organoid On-chip platform Osteochondral unit Ex-vivo disease model |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X23000166 |
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