B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia
We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly norma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-09-01
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| Series: | Pediatric Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/pr/article/view/2544 |
| _version_ | 1818383214401552384 |
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| author | Esther de Vries Eugenie F.A. Gemen Ellen J.H. Schatorjé Annemieke M. van der Weij Annelieke A.A. van der Linde |
| author_facet | Esther de Vries Eugenie F.A. Gemen Ellen J.H. Schatorjé Annemieke M. van der Weij Annelieke A.A. van der Linde |
| author_sort | Esther de Vries |
| collection | DOAJ |
| description | We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values. |
| first_indexed | 2024-12-14T03:02:48Z |
| format | Article |
| id | doaj.art-7c3d36a595554ba29074abb2a29b1cf4 |
| institution | Directory Open Access Journal |
| issn | 2036-749X 2036-7503 |
| language | English |
| last_indexed | 2024-12-14T03:02:48Z |
| publishDate | 2011-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-7c3d36a595554ba29074abb2a29b1cf42022-12-21T23:19:28ZengMDPI AGPediatric Reports2036-749X2036-75032011-09-0134e28e2810.4081/pr.2011.e28B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemiaEsther de VriesEugenie F.A. GemenEllen J.H. SchatorjéAnnemieke M. van der WeijAnnelieke A.A. van der LindeWe report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.http://www.pagepress.org/journals/index.php/pr/article/view/2544Autoimmune hemolytic anemiaRituximabChildImmune reconstitutionB-lymphocytes |
| spellingShingle | Esther de Vries Eugenie F.A. Gemen Ellen J.H. Schatorjé Annemieke M. van der Weij Annelieke A.A. van der Linde B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia Pediatric Reports Autoimmune hemolytic anemia Rituximab Child Immune reconstitution B-lymphocytes |
| title | B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia |
| title_full | B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia |
| title_fullStr | B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia |
| title_full_unstemmed | B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia |
| title_short | B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia |
| title_sort | b lymphocyte reconstitution after repeated rituximab treatment in a child with steroid dependent autoimmune hemolytic anemia |
| topic | Autoimmune hemolytic anemia Rituximab Child Immune reconstitution B-lymphocytes |
| url | http://www.pagepress.org/journals/index.php/pr/article/view/2544 |
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