Aberrant activity in degenerated retinas revealed by electrical imaging
In this review I present and discuss the current understanding of aberrant electrical activity found in the ganglion cell layer (GCL) of rod-degenerated (rd) mouse retinas. The reported electrophysiological properties revealed by electrical imaging using high-density microelectrode arrays can be sub...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00025/full |
| _version_ | 1819238422544384000 |
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| author | Günther eZeck |
| author_facet | Günther eZeck |
| author_sort | Günther eZeck |
| collection | DOAJ |
| description | In this review I present and discuss the current understanding of aberrant electrical activity found in the ganglion cell layer (GCL) of rod-degenerated (rd) mouse retinas. The reported electrophysiological properties revealed by electrical imaging using high-density microelectrode arrays can be subdivided between spiking activity originating from retinal ganglion cells (RGCs) and local field potentials reflecting strong trans-membrane currents within the GCL. RGCs in rod-degenerated retinas show increased and rhythmic spiking compared to age-matched wild-type retinas. Fundamental spiking frequencies range from 5 to 15 Hz in various mouse models. The rhythmic RGC spiking is driven by a presynaptic network comprising AII amacrine and bipolar cells. In the healthy retina this rhythm-generating circuit is inhibited by photoreceptor input. A unique physiological feature of rd retinas is rhythmic local field potentials (LFP) manifested as spatially-restricted low-frequency (5–15 Hz) voltage changes. Their spatiotemporal characterization revealed propagation and correlation with RGC spiking. LFPs rely on gap-junctional coupling and are shaped by glycinergic and by GABAergic transmission. The aberrant RGC spiking and LFPs provide a simple readout of the functionality of the remaining retinal circuitry which can be used in the development of improved vision restoration strategies. |
| first_indexed | 2024-12-23T13:35:58Z |
| format | Article |
| id | doaj.art-7c415b54057e400c80251faf03b72618 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-23T13:35:58Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-7c415b54057e400c80251faf03b726182022-12-21T17:45:01ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022016-02-011010.3389/fncel.2016.00025178108Aberrant activity in degenerated retinas revealed by electrical imagingGünther eZeck0Natural and Medical Sciences Institute at the University of TübingenIn this review I present and discuss the current understanding of aberrant electrical activity found in the ganglion cell layer (GCL) of rod-degenerated (rd) mouse retinas. The reported electrophysiological properties revealed by electrical imaging using high-density microelectrode arrays can be subdivided between spiking activity originating from retinal ganglion cells (RGCs) and local field potentials reflecting strong trans-membrane currents within the GCL. RGCs in rod-degenerated retinas show increased and rhythmic spiking compared to age-matched wild-type retinas. Fundamental spiking frequencies range from 5 to 15 Hz in various mouse models. The rhythmic RGC spiking is driven by a presynaptic network comprising AII amacrine and bipolar cells. In the healthy retina this rhythm-generating circuit is inhibited by photoreceptor input. A unique physiological feature of rd retinas is rhythmic local field potentials (LFP) manifested as spatially-restricted low-frequency (5–15 Hz) voltage changes. Their spatiotemporal characterization revealed propagation and correlation with RGC spiking. LFPs rely on gap-junctional coupling and are shaped by glycinergic and by GABAergic transmission. The aberrant RGC spiking and LFPs provide a simple readout of the functionality of the remaining retinal circuitry which can be used in the development of improved vision restoration strategies.http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00025/fullmicroelectrode arrayextracellular recordingganglion cellsMouse Retinarod-degeneration |
| spellingShingle | Günther eZeck Aberrant activity in degenerated retinas revealed by electrical imaging Frontiers in Cellular Neuroscience microelectrode array extracellular recording ganglion cells Mouse Retina rod-degeneration |
| title | Aberrant activity in degenerated retinas revealed by electrical imaging |
| title_full | Aberrant activity in degenerated retinas revealed by electrical imaging |
| title_fullStr | Aberrant activity in degenerated retinas revealed by electrical imaging |
| title_full_unstemmed | Aberrant activity in degenerated retinas revealed by electrical imaging |
| title_short | Aberrant activity in degenerated retinas revealed by electrical imaging |
| title_sort | aberrant activity in degenerated retinas revealed by electrical imaging |
| topic | microelectrode array extracellular recording ganglion cells Mouse Retina rod-degeneration |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00025/full |
| work_keys_str_mv | AT guntherezeck aberrantactivityindegeneratedretinasrevealedbyelectricalimaging |