Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications
In recent years, increasing interest has been placed in the development of Zn alloys for absorbable biomedical applications. It has been demonstrated that these alloys are potential candidates for endovascular applications. In the present work, a novel Zn-12.5Ag-1Mg alloy was investigated as a poten...
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MDPI AG
2020-04-01
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| Online Access: | https://www.mdpi.com/2075-4701/10/5/586 |
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| author | Ana Laura Ramirez–Ledesma Paola Roncagliolo–Barrera Carlo Paternoster Riccardo Casati Hugo Lopez Maurizio Vedani Diego Mantovani |
| author_facet | Ana Laura Ramirez–Ledesma Paola Roncagliolo–Barrera Carlo Paternoster Riccardo Casati Hugo Lopez Maurizio Vedani Diego Mantovani |
| author_sort | Ana Laura Ramirez–Ledesma |
| collection | DOAJ |
| description | In recent years, increasing interest has been placed in the development of Zn alloys for absorbable biomedical applications. It has been demonstrated that these alloys are potential candidates for endovascular applications. In the present work, a novel Zn-12.5Ag-1Mg alloy was investigated as a potential biomedical absorbable material. As a reference, the exhibited biocompatible properties are compared with those of pure Zn and a Zn-1Mg alloy. All the alloys investigated in this work were cast in a water-cooled Cu-mold (chill casting). Subsequently, the alloys were solution-treated and then extruded. The microstructural evolution at each stage of the alloy processing was resolved by analytical means including optical, scanning, transmission microscopy, and X-ray diffraction. By these means, the various phases belonging to this alloy system were disclosed. In addition, determinations of both corrosion and mechanical properties were carried out in the proposed Zn-12.5Ag-1Mg alloy. In particular, an excellent combination of strength and ductility was found, which is attributed to grain refinement as well as the precipitation of a uniform distribution of refined phases (i.e., AgZn solid solution, ε-AgZn<sub>3</sub>, and Ag<sub>0.15</sub>MgZn<sub>1.85</sub> intermetallics). All the precipitated intermetallics were embedded in a η-Zn matrix. As for the corrosion degradation in the physiological NaCl solution in the as-extruded condition, the experimental outcome indicates that the Zn-12.5Ag-1Mg alloy exhibits degradation rates far superior to currently reported ones for Zn-based alloys intended for absorbable biomedical applications. |
| first_indexed | 2024-03-10T20:08:28Z |
| format | Article |
| id | doaj.art-7c419bbe6ee3438597273b49ef3ca5b7 |
| institution | Directory Open Access Journal |
| issn | 2075-4701 |
| language | English |
| last_indexed | 2024-03-10T20:08:28Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metals |
| spelling | doaj.art-7c419bbe6ee3438597273b49ef3ca5b72023-11-19T23:04:36ZengMDPI AGMetals2075-47012020-04-0110558610.3390/met10050586Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical ApplicationsAna Laura Ramirez–Ledesma0Paola Roncagliolo–Barrera1Carlo Paternoster2Riccardo Casati3Hugo Lopez4Maurizio Vedani5Diego Mantovani6Departamento de Ingeniería Metalúrgica, Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior S/N, Cd. Universitaria, 04510 Ciudad de México, MexicoDepartamento de Ingeniería Metalúrgica, Facultad de Química, Universidad Nacional Autónoma de México, Av. Universidad 3000, Circuito Exterior S/N, Cd. Universitaria, 04510 Ciudad de México, MexicoLab. for Biomaterials & Bioengineering (CRC—I), Dept. Min—Met—Materials Engineering & Research Center CHU de Québec, Laval University, Québec, QC G1V 0A6, CanadaDepartment of Mechanical Engineering, Politecnico di Milano, 20133 Milan, ItalyMaterials Science and Engineering Department, CEAS University of Wisconsin-Milwaukee 3200 N. Cramer Street, Milwaukee, WI 53211, USADepartment of Mechanical Engineering, Politecnico di Milano, 20133 Milan, ItalyLab. for Biomaterials & Bioengineering (CRC—I), Dept. Min—Met—Materials Engineering & Research Center CHU de Québec, Laval University, Québec, QC G1V 0A6, CanadaIn recent years, increasing interest has been placed in the development of Zn alloys for absorbable biomedical applications. It has been demonstrated that these alloys are potential candidates for endovascular applications. In the present work, a novel Zn-12.5Ag-1Mg alloy was investigated as a potential biomedical absorbable material. As a reference, the exhibited biocompatible properties are compared with those of pure Zn and a Zn-1Mg alloy. All the alloys investigated in this work were cast in a water-cooled Cu-mold (chill casting). Subsequently, the alloys were solution-treated and then extruded. The microstructural evolution at each stage of the alloy processing was resolved by analytical means including optical, scanning, transmission microscopy, and X-ray diffraction. By these means, the various phases belonging to this alloy system were disclosed. In addition, determinations of both corrosion and mechanical properties were carried out in the proposed Zn-12.5Ag-1Mg alloy. In particular, an excellent combination of strength and ductility was found, which is attributed to grain refinement as well as the precipitation of a uniform distribution of refined phases (i.e., AgZn solid solution, ε-AgZn<sub>3</sub>, and Ag<sub>0.15</sub>MgZn<sub>1.85</sub> intermetallics). All the precipitated intermetallics were embedded in a η-Zn matrix. As for the corrosion degradation in the physiological NaCl solution in the as-extruded condition, the experimental outcome indicates that the Zn-12.5Ag-1Mg alloy exhibits degradation rates far superior to currently reported ones for Zn-based alloys intended for absorbable biomedical applications.https://www.mdpi.com/2075-4701/10/5/586Zn-based alloysabsorbable materialsextrusionmechanical propertiesHRTEM characterizationcorrosion behavior |
| spellingShingle | Ana Laura Ramirez–Ledesma Paola Roncagliolo–Barrera Carlo Paternoster Riccardo Casati Hugo Lopez Maurizio Vedani Diego Mantovani Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications Metals Zn-based alloys absorbable materials extrusion mechanical properties HRTEM characterization corrosion behavior |
| title | Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications |
| title_full | Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications |
| title_fullStr | Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications |
| title_full_unstemmed | Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications |
| title_short | Microstructural Precipitation Evolution and In Vitro Degradation Behavior of a Novel Chill-Cast Zn-Based Absorbable Alloy for Medical Applications |
| title_sort | microstructural precipitation evolution and in vitro degradation behavior of a novel chill cast zn based absorbable alloy for medical applications |
| topic | Zn-based alloys absorbable materials extrusion mechanical properties HRTEM characterization corrosion behavior |
| url | https://www.mdpi.com/2075-4701/10/5/586 |
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