Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus
Introduction: Peripheral neuropathy is a common microvascular complication in patients with type 2 diabetes mellitus with a prevalence of around 50%. Objectives: This prospective observational cross-sectional study was done to assess serum calprotectin levels among diabetic patients with peripheral...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=4;spage=1602;epage=1606;aulast=Velayutham |
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| author | Ramanathan Velayutham Pradeep Pankajakshan Nair Prashant S Adole Vadivelan Mehalingam |
| author_facet | Ramanathan Velayutham Pradeep Pankajakshan Nair Prashant S Adole Vadivelan Mehalingam |
| author_sort | Ramanathan Velayutham |
| collection | DOAJ |
| description | Introduction: Peripheral neuropathy is a common microvascular complication in patients with type 2 diabetes mellitus with a prevalence of around 50%. Objectives: This prospective observational cross-sectional study was done to assess serum calprotectin levels among diabetic patients with peripheral neuropathy as compared to those without neuropathy. Methods: This cross-sectional study was conducted in 126 diabetic patients attending the out-patient department of JIPMER Hospital, Pondicherry from July 2017 to January 2019. The subjects were divided into two groups (with and without peripheral neuropathy) and underwent nerve conduction study of both the lower limbs. Blood samples were collected and stored at −80°C for estimation of serum calprotectin. Serum calprotectin levels were compared between diabetic patients with and without peripheral neuropathy. Results: Serum calprotectin levels were increased in patients with diabetic peripheral neuropathy (DPN) as compared to those without DPN. However, there was no significant difference in the mean value of serum calprotectin among the various sub-groups of DPN. Conclusion: Serum calprotectin, an inflammatory biomarker is elevated in patients with diabetic peripheral neuropathy as compared to those without neuropathy. |
| first_indexed | 2024-12-17T07:25:40Z |
| format | Article |
| id | doaj.art-7c431fbbeb804e90aca5ed9c63536ed6 |
| institution | Directory Open Access Journal |
| issn | 2249-4863 |
| language | English |
| last_indexed | 2024-12-17T07:25:40Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj.art-7c431fbbeb804e90aca5ed9c63536ed62022-12-21T21:58:38ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632021-01-011041602160610.4103/jfmpc.jfmpc_1165_20Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitusRamanathan VelayuthamPradeep Pankajakshan NairPrashant S AdoleVadivelan MehalingamIntroduction: Peripheral neuropathy is a common microvascular complication in patients with type 2 diabetes mellitus with a prevalence of around 50%. Objectives: This prospective observational cross-sectional study was done to assess serum calprotectin levels among diabetic patients with peripheral neuropathy as compared to those without neuropathy. Methods: This cross-sectional study was conducted in 126 diabetic patients attending the out-patient department of JIPMER Hospital, Pondicherry from July 2017 to January 2019. The subjects were divided into two groups (with and without peripheral neuropathy) and underwent nerve conduction study of both the lower limbs. Blood samples were collected and stored at −80°C for estimation of serum calprotectin. Serum calprotectin levels were compared between diabetic patients with and without peripheral neuropathy. Results: Serum calprotectin levels were increased in patients with diabetic peripheral neuropathy (DPN) as compared to those without DPN. However, there was no significant difference in the mean value of serum calprotectin among the various sub-groups of DPN. Conclusion: Serum calprotectin, an inflammatory biomarker is elevated in patients with diabetic peripheral neuropathy as compared to those without neuropathy.http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=4;spage=1602;epage=1606;aulast=Velayuthamcalprotectindiabetic peripheral neuropathynerve conduction study |
| spellingShingle | Ramanathan Velayutham Pradeep Pankajakshan Nair Prashant S Adole Vadivelan Mehalingam Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus Journal of Family Medicine and Primary Care calprotectin diabetic peripheral neuropathy nerve conduction study |
| title | Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_full | Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_fullStr | Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_short | Association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus |
| title_sort | association of serum calprotectin with peripheral neuropathy in patients with type 2 diabetes mellitus |
| topic | calprotectin diabetic peripheral neuropathy nerve conduction study |
| url | http://www.jfmpc.com/article.asp?issn=2249-4863;year=2021;volume=10;issue=4;spage=1602;epage=1606;aulast=Velayutham |
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