Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature
INTRODUCTION[|]Malignant Brenner tumors (MBT) of the ovary are rare diseases, representing 1% of all ovarian cancers and 3-5% of Brenner tumors. They carry a poor prognosis. They generally affect women during the perimenopausal and postmenopausal periods. The standard treatment is surgery; however,...
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| Format: | Article |
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Turkish Foundation of Family Medicine
2020-04-01
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| Series: | Anatolian Journal of Family Medicine |
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| Online Access: | https://www.journalagent.com/z4/download_fulltext.asp?pdir=anatoljfm&un=ANATOLJFM-66375 |
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| author | Malek Bouhani Maher Slimane Sarah Sghaier Amine Bouida Riadh Chargui Khaled Rahal |
| author_facet | Malek Bouhani Maher Slimane Sarah Sghaier Amine Bouida Riadh Chargui Khaled Rahal |
| author_sort | Malek Bouhani |
| collection | DOAJ |
| description | INTRODUCTION[|]Malignant Brenner tumors (MBT) of the ovary are rare diseases, representing 1% of all ovarian cancers and 3-5% of Brenner tumors. They carry a poor prognosis. They generally affect women during the perimenopausal and postmenopausal periods. The standard treatment is surgery; however, the indication of adjuvant chemotherapy remains controversial. The present study aims to report our experience in the treatment of MBT of the ovary, to better characterize this disease.[¤]METHODS[|]In this study, a retrospective case series involving four patients diagnosed with MBT of the ovary and treated between 2006 and 2014.[¤]RESULTS[|]Four cases of MBT of the ovary were diagnosed over a seven-year period. The mean age of our patients was 59.3+-11.1 years. Three patients were in the menopause period. The tumor was staged as IC in one case, IIC in one case, and IIIC in two cases of the International Federation of Gynecology and Obstetrics classification. All patients underwent surgery, followed by adjuvant chemotherapy. Three patients underwent a loco-regional recurrence that occurred respectively, after nine months in one patient and 11 months in two patients. The treatment was based on chemotherapy combined with surgery in one case. Two patients presented distant metastasis. The treatment consisted of chemotherapy and surgery. The median follows up period was 49.0 (14.0-64.0) months.[¤]DISCUSSION AND CONCLUSION[|]The treatment approach of MBT of the ovary is not well established since its scarcity and poor prognosis. Thus, more case series and meta-analysis should be conducted.[¤] |
| first_indexed | 2024-04-10T10:22:18Z |
| format | Article |
| id | doaj.art-7c447538333243ab984f94b58aa4549f |
| institution | Directory Open Access Journal |
| issn | 2651-3455 |
| language | English |
| last_indexed | 2024-04-10T10:22:18Z |
| publishDate | 2020-04-01 |
| publisher | Turkish Foundation of Family Medicine |
| record_format | Article |
| series | Anatolian Journal of Family Medicine |
| spelling | doaj.art-7c447538333243ab984f94b58aa4549f2023-02-15T16:21:32ZengTurkish Foundation of Family MedicineAnatolian Journal of Family Medicine2651-34552020-04-0131717510.5505/anatoljfm.2019.66375ANATOLJFM-66375Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the LiteratureMalek Bouhani0Maher Slimane1Sarah Sghaier2Amine Bouida3Riadh Chargui4Khaled Rahal5Department of Oncologic Surgery, Salah Azaiz Institute, Tunis, TunisiaDepartment of Oncologic Surgery, Salah Azaiz Institute, Tunis, TunisiaDepartment of Oncologic Surgery, Salah Azaiz Institute, Tunis, TunisiaDepartment of Oncologic Surgery, Salah Azaiz Institute, Tunis, TunisiaDepartment of Oncologic Surgery, Salah Azaiz Institute, Tunis, TunisiaDepartment of Oncologic Surgery, Salah Azaiz Institute, Tunis, TunisiaINTRODUCTION[|]Malignant Brenner tumors (MBT) of the ovary are rare diseases, representing 1% of all ovarian cancers and 3-5% of Brenner tumors. They carry a poor prognosis. They generally affect women during the perimenopausal and postmenopausal periods. The standard treatment is surgery; however, the indication of adjuvant chemotherapy remains controversial. The present study aims to report our experience in the treatment of MBT of the ovary, to better characterize this disease.[¤]METHODS[|]In this study, a retrospective case series involving four patients diagnosed with MBT of the ovary and treated between 2006 and 2014.[¤]RESULTS[|]Four cases of MBT of the ovary were diagnosed over a seven-year period. The mean age of our patients was 59.3+-11.1 years. Three patients were in the menopause period. The tumor was staged as IC in one case, IIC in one case, and IIIC in two cases of the International Federation of Gynecology and Obstetrics classification. All patients underwent surgery, followed by adjuvant chemotherapy. Three patients underwent a loco-regional recurrence that occurred respectively, after nine months in one patient and 11 months in two patients. The treatment was based on chemotherapy combined with surgery in one case. Two patients presented distant metastasis. The treatment consisted of chemotherapy and surgery. The median follows up period was 49.0 (14.0-64.0) months.[¤]DISCUSSION AND CONCLUSION[|]The treatment approach of MBT of the ovary is not well established since its scarcity and poor prognosis. Thus, more case series and meta-analysis should be conducted.[¤]https://www.journalagent.com/z4/download_fulltext.asp?pdir=anatoljfm&un=ANATOLJFM-66375brenner tumorovarylymph node excisionprognosisoperative surgical procedure |
| spellingShingle | Malek Bouhani Maher Slimane Sarah Sghaier Amine Bouida Riadh Chargui Khaled Rahal Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature Anatolian Journal of Family Medicine brenner tumor ovary lymph node excision prognosis operative surgical procedure |
| title | Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature |
| title_full | Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature |
| title_fullStr | Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature |
| title_full_unstemmed | Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature |
| title_short | Malignant Brenner Tumor of the Ovary: One Single Institute Experience and a Review of the Literature |
| title_sort | malignant brenner tumor of the ovary one single institute experience and a review of the literature |
| topic | brenner tumor ovary lymph node excision prognosis operative surgical procedure |
| url | https://www.journalagent.com/z4/download_fulltext.asp?pdir=anatoljfm&un=ANATOLJFM-66375 |
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