Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp.
The marine sponge of the genus <i>Geodia</i>, <i>Jaspis</i>, <i>Rhabdastrella</i>, and <i>Stelletta</i> are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to th...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/19/4/206 |
| Summary: | The marine sponge of the genus <i>Geodia</i>, <i>Jaspis</i>, <i>Rhabdastrella</i>, and <i>Stelletta</i> are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (<b>1</b>) and rhabdastin I (<b>2</b>). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds <b>1</b> and <b>2</b> showed activities against K562 (IC<sub>50</sub> 11.7 and 9.8 μM) and Molt4 (IC<sub>50</sub> 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay. |
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| ISSN: | 1660-3397 |