Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp.
The marine sponge of the genus <i>Geodia</i>, <i>Jaspis</i>, <i>Rhabdastrella</i>, and <i>Stelletta</i> are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/19/4/206 |
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| author | Kuei-Hung Lai Zheng-Hao Huang Mohamed El-Shazly Bo-Rong Peng Wen-Chi Wei Jui-Hsin Su |
| author_facet | Kuei-Hung Lai Zheng-Hao Huang Mohamed El-Shazly Bo-Rong Peng Wen-Chi Wei Jui-Hsin Su |
| author_sort | Kuei-Hung Lai |
| collection | DOAJ |
| description | The marine sponge of the genus <i>Geodia</i>, <i>Jaspis</i>, <i>Rhabdastrella</i>, and <i>Stelletta</i> are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (<b>1</b>) and rhabdastin I (<b>2</b>). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds <b>1</b> and <b>2</b> showed activities against K562 (IC<sub>50</sub> 11.7 and 9.8 μM) and Molt4 (IC<sub>50</sub> 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay. |
| first_indexed | 2024-03-10T12:34:55Z |
| format | Article |
| id | doaj.art-7c44d358ab4e4a7dab9a4a6dcb9b0292 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T12:34:55Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-7c44d358ab4e4a7dab9a4a6dcb9b02922023-11-21T14:21:16ZengMDPI AGMarine Drugs1660-33972021-04-0119420610.3390/md19040206Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp.Kuei-Hung Lai0Zheng-Hao Huang1Mohamed El-Shazly2Bo-Rong Peng3Wen-Chi Wei4Jui-Hsin Su5PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, TaiwanNational Museum of Marine Biology & Aquarium, Pingtung 94450, TaiwanDepartment of Pharmaceutical Biology, German University in Cairo, Cairo 11432, EgyptNational Museum of Marine Biology & Aquarium, Pingtung 94450, TaiwanDivision of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Taipei 11221, TaiwanNational Museum of Marine Biology & Aquarium, Pingtung 94450, TaiwanThe marine sponge of the genus <i>Geodia</i>, <i>Jaspis</i>, <i>Rhabdastrella</i>, and <i>Stelletta</i> are characterized chemically by a variety of isomalabaricane triterpenes. This class of compounds drew spotlights in marine lead discovery due to their profound anti-proliferative properties. Further research on exploring its chemical diversity led to the identifications of two new isomalabaricane-type triterpenes rhabdastin H (<b>1</b>) and rhabdastin I (<b>2</b>). Their structures were unraveled using a series of spectroscopic approaches. These isolates were found to exhibit unique structural features with the only reported tetrahydrofuran functionality among all marine-derived isomalabaricanes. Both compounds <b>1</b> and <b>2</b> showed activities against K562 (IC<sub>50</sub> 11.7 and 9.8 μM) and Molt4 (IC<sub>50</sub> 16.5 and 11.0 μM) leukemic cells in MTT cell proliferative assay.https://www.mdpi.com/1660-3397/19/4/206isomalabaricanetetrahydrofuran moietyanti-leukemia |
| spellingShingle | Kuei-Hung Lai Zheng-Hao Huang Mohamed El-Shazly Bo-Rong Peng Wen-Chi Wei Jui-Hsin Su Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp. Marine Drugs isomalabaricane tetrahydrofuran moiety anti-leukemia |
| title | Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp. |
| title_full | Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp. |
| title_fullStr | Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp. |
| title_full_unstemmed | Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp. |
| title_short | Isomalabaricane Triterpenes from the Marine Sponge <i>Rhabdastrella</i> sp. |
| title_sort | isomalabaricane triterpenes from the marine sponge i rhabdastrella i sp |
| topic | isomalabaricane tetrahydrofuran moiety anti-leukemia |
| url | https://www.mdpi.com/1660-3397/19/4/206 |
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