CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus
The levels of soluble CD40L (sCD40L) and other inflammatory and thrombotic markers were studied in coronary heart disease (CHD)) patients with or without Type 2 diabetes mellitus (DM-2). In total, 56 patients with various CHD forms, as well as 10 healthy volunteers, were examined. In 12 patients, CD...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2006-10-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1944 |
| _version_ | 1797857224241971200 |
|---|---|
| author | O. P. Shevchenko O. F. Prirodova O. V. Orlova A. O. Shevchenko |
| author_facet | O. P. Shevchenko O. F. Prirodova O. V. Orlova A. O. Shevchenko |
| author_sort | O. P. Shevchenko |
| collection | DOAJ |
| description | The levels of soluble CD40L (sCD40L) and other inflammatory and thrombotic markers were studied in coronary heart disease (CHD)) patients with or without Type 2 diabetes mellitus (DM-2). In total, 56 patients with various CHD forms, as well as 10 healthy volunteers, were examined. In 12 patients, CD-2 was diagnosed. In all participants, the levels of high-sensitive С-reactive protein (hsCRP), fibrinogen, tumor necrosis factor-alpha (TNO-alpha), pregnancy-associated plasma protein A (PAPP-A), soluble vascular cell adhesion molecule-1 (s VCAM-1), and sCD40I were measured. Inpatients with CHD and DM-2 (Group I, n = 12), sCD40I levels were significantly higher than in CHD patients without DM-2 (Group II, n = 44), or control group: 3,07 ± 2,03, 1,72 ± 1,54, and 1,05 ± 1,07 ng/ml, respectively (p < 0, 05). Other marker levels were similar in Groups land II There was no significant sCD40I level difference among subgroups with various CHD forms. Among other cardiovascular risk factors, sCD40L levels correlated significantly with plasma triglyceride levels (p = 0,028; r = -0,301). CHD patients with DM-2 demonstrated significantly higher sCD40L plasma levels, in comparison with diabetes-free CHD patients or healthy individuals, regardless of CHD form or main cardiovascular risk factors. |
| first_indexed | 2024-04-09T20:54:19Z |
| format | Article |
| id | doaj.art-7c46ec53dcba496caada10585b68b4c6 |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2024-04-09T20:54:19Z |
| publishDate | 2006-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj.art-7c46ec53dcba496caada10585b68b4c62023-03-29T21:23:13Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202006-10-010523281702CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitusO. P. Shevchenko0O. F. Prirodova1O. V. Orlova2A. O. Shevchenko3Российский государственный медицинский университет, кафедра кардиологии ФУВ; Клиническая больница управления делами Президента РФ; НИИ Трансплантологии и искусственных органовРоссийский государственный медицинский университет, кафедра кардиологии ФУВ; Клиническая больница управления делами Президента РФ; НИИ Трансплантологии и искусственных органовРоссийский государственный медицинский университет, кафедра кардиологии ФУВ; Клиническая больница управления делами Президента РФ; НИИ Трансплантологии и искусственных органовРоссийский государственный медицинский университет, кафедра кардиологии ФУВ; Клиническая больница управления делами Президента РФ; НИИ Трансплантологии и искусственных органовThe levels of soluble CD40L (sCD40L) and other inflammatory and thrombotic markers were studied in coronary heart disease (CHD)) patients with or without Type 2 diabetes mellitus (DM-2). In total, 56 patients with various CHD forms, as well as 10 healthy volunteers, were examined. In 12 patients, CD-2 was diagnosed. In all participants, the levels of high-sensitive С-reactive protein (hsCRP), fibrinogen, tumor necrosis factor-alpha (TNO-alpha), pregnancy-associated plasma protein A (PAPP-A), soluble vascular cell adhesion molecule-1 (s VCAM-1), and sCD40I were measured. Inpatients with CHD and DM-2 (Group I, n = 12), sCD40I levels were significantly higher than in CHD patients without DM-2 (Group II, n = 44), or control group: 3,07 ± 2,03, 1,72 ± 1,54, and 1,05 ± 1,07 ng/ml, respectively (p < 0, 05). Other marker levels were similar in Groups land II There was no significant sCD40I level difference among subgroups with various CHD forms. Among other cardiovascular risk factors, sCD40L levels correlated significantly with plasma triglyceride levels (p = 0,028; r = -0,301). CHD patients with DM-2 demonstrated significantly higher sCD40L plasma levels, in comparison with diabetes-free CHD patients or healthy individuals, regardless of CHD form or main cardiovascular risk factors.https://russjcardiol.elpub.ru/jour/article/view/1944coronary heart deseasetype 2 diabetes mellitusinflammatory and thrombotic markers |
| spellingShingle | O. P. Shevchenko O. F. Prirodova O. V. Orlova A. O. Shevchenko CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus Российский кардиологический журнал coronary heart desease type 2 diabetes mellitus inflammatory and thrombotic markers |
| title | CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus |
| title_full | CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus |
| title_fullStr | CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus |
| title_full_unstemmed | CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus |
| title_short | CD40 ligand in coronary heart disease patients with Type 2 diabetes mellitus |
| title_sort | cd40 ligand in coronary heart disease patients with type 2 diabetes mellitus |
| topic | coronary heart desease type 2 diabetes mellitus inflammatory and thrombotic markers |
| url | https://russjcardiol.elpub.ru/jour/article/view/1944 |
| work_keys_str_mv | AT opshevchenko cd40ligandincoronaryheartdiseasepatientswithtype2diabetesmellitus AT ofprirodova cd40ligandincoronaryheartdiseasepatientswithtype2diabetesmellitus AT ovorlova cd40ligandincoronaryheartdiseasepatientswithtype2diabetesmellitus AT aoshevchenko cd40ligandincoronaryheartdiseasepatientswithtype2diabetesmellitus |