The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats
Background & objectives: Considering the importance of liver toxicity due to drugs and toxins as a major cause of liver damage, this study was conducted to evaluate the effects of the combination of cinnamon and ginger extracts on serum biochemical parameters in carbon tetrachloride (CCl4)- into...
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Ardabil University of Medical Sciences
2019-03-01
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| Series: | Journal of Ardabil University of Medical Sciences |
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| Online Access: | http://jarums.arums.ac.ir/browse.php?a_code=A-10-1283-1&slc_lang=en&sid=1 |
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| author | Masoud Ojarudi Mohammad Mazani Reza Hajihosseini Alireza Moradi Lotfollah Rezagholizadeh |
| author_facet | Masoud Ojarudi Mohammad Mazani Reza Hajihosseini Alireza Moradi Lotfollah Rezagholizadeh |
| author_sort | Masoud Ojarudi |
| collection | DOAJ |
| description | Background & objectives: Considering the importance of liver toxicity due to drugs and toxins as a major cause of liver damage, this study was conducted to evaluate the effects of the combination of cinnamon and ginger extracts on serum biochemical parameters in carbon tetrachloride (CCl4)- intoxicated rats.
Methods: In this experimental study, forty-two male Wistar rats were divided into 7 groups (n=6). Three control groups including normal control, combined extract control and damaged control were designated that received distilled water, a mixture of cinnamon and ginger extracts and distilled water respectively for 14 days.
Other 4 groups were pre-treatment groups which were treated with cinnamon (50 mg/kg/d), ginger (250 mg/kg/d), cinnamon + ginger (25+125 mg/kg/d) and silymarin (100 mg/kg/d) respectively for 14 days before being damaged by intraperitoneal injection of CCl4 (1 ml/kg, 1:1 in olive oil). Fifty - two hours after CCl4 injection, blood sampling was performed and biochemical parameters were measured in serum of rats.
Results: The results of this study showed that the injection of CCl4 significantly increased the ALT and AST enzymes activity ,cholesterol, triglyceride, and LDL levels and decreased the blood albumin and HDL levels in damaged rats compared to the normal control group (p<0.001). However, pre-treatment with the cinnamon and ginger extracts, especially combination of extracts significantly improved these values compared to the CCl4 damage group (p<0.001).
Conclusion: The results suggest that simultaneous use of cinnamon and ginger extracts has more significant protective effects against CCl4-induced hepatotoxicity. |
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| issn | 2228-7280 2228-7299 |
| language | fas |
| last_indexed | 2024-12-14T20:08:14Z |
| publishDate | 2019-03-01 |
| publisher | Ardabil University of Medical Sciences |
| record_format | Article |
| series | Journal of Ardabil University of Medical Sciences |
| spelling | doaj.art-7c47f2d0fcdd49d5a3001dc68e811dc62022-12-21T22:48:59ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992019-03-01184429439The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated RatsMasoud Ojarudi0Mohammad Mazani1Reza Hajihosseini2Alireza Moradi3Lotfollah Rezagholizadeh4 Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran Department of Physiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran Background & objectives: Considering the importance of liver toxicity due to drugs and toxins as a major cause of liver damage, this study was conducted to evaluate the effects of the combination of cinnamon and ginger extracts on serum biochemical parameters in carbon tetrachloride (CCl4)- intoxicated rats. Methods: In this experimental study, forty-two male Wistar rats were divided into 7 groups (n=6). Three control groups including normal control, combined extract control and damaged control were designated that received distilled water, a mixture of cinnamon and ginger extracts and distilled water respectively for 14 days. Other 4 groups were pre-treatment groups which were treated with cinnamon (50 mg/kg/d), ginger (250 mg/kg/d), cinnamon + ginger (25+125 mg/kg/d) and silymarin (100 mg/kg/d) respectively for 14 days before being damaged by intraperitoneal injection of CCl4 (1 ml/kg, 1:1 in olive oil). Fifty - two hours after CCl4 injection, blood sampling was performed and biochemical parameters were measured in serum of rats. Results: The results of this study showed that the injection of CCl4 significantly increased the ALT and AST enzymes activity ,cholesterol, triglyceride, and LDL levels and decreased the blood albumin and HDL levels in damaged rats compared to the normal control group (p<0.001). However, pre-treatment with the cinnamon and ginger extracts, especially combination of extracts significantly improved these values compared to the CCl4 damage group (p<0.001). Conclusion: The results suggest that simultaneous use of cinnamon and ginger extracts has more significant protective effects against CCl4-induced hepatotoxicity.http://jarums.arums.ac.ir/browse.php?a_code=A-10-1283-1&slc_lang=en&sid=1CinnamonGingerCarbon TetrachlorideBiochemical ParametersSynergistic EffectRat |
| spellingShingle | Masoud Ojarudi Mohammad Mazani Reza Hajihosseini Alireza Moradi Lotfollah Rezagholizadeh The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats Journal of Ardabil University of Medical Sciences Cinnamon Ginger Carbon Tetrachloride Biochemical Parameters Synergistic Effect Rat |
| title | The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats |
| title_full | The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats |
| title_fullStr | The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats |
| title_full_unstemmed | The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats |
| title_short | The Synergistic Effects of Hydroalcoholic Extracts of Cinnamon and Ginger on the Biochemical Parameters of CCl4-Intoxicated Rats |
| title_sort | synergistic effects of hydroalcoholic extracts of cinnamon and ginger on the biochemical parameters of ccl4 intoxicated rats |
| topic | Cinnamon Ginger Carbon Tetrachloride Biochemical Parameters Synergistic Effect Rat |
| url | http://jarums.arums.ac.ir/browse.php?a_code=A-10-1283-1&slc_lang=en&sid=1 |
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