One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation

One-Pot Synthesis of (Z)-β-Halovinyl Ketones via the Cascade of Sonogashira Coupling and Hydrohalogenation

Herein, we report an efficient method for the synthesis of (Z)-β-halovinyl ketones through a one-pot Sonogashira coupling and hydrohalogenation reaction promoted by palladium-copper catalyst and Brønsted acid. The ynone intermediates are generated in situ from readily available acid chlorides and te...

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Bibliographic Details
Main Authors:	Fa-Jie Chen, Zhenguo Hua, Jianhui Chen, Jiajia Chen, Daesung Lee, Yuanzhi Xia
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Chemistry
Subjects:	Sonogashira coupling one-pot synthesis β-halovinyl ketone hydrohalogenation ynones
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2020.621545/full

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