Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice
Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isofo...
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| Format: | Article |
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eLife Sciences Publications Ltd
2016-02-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/11742 |
| _version_ | 1818019000914804736 |
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| author | Damien Lanfray Alexandre Caron Marie-Claude Roy Mathieu Laplante Fabrice Morin Jérôme Leprince Marie-Christine Tonon Denis Richard |
| author_facet | Damien Lanfray Alexandre Caron Marie-Claude Roy Mathieu Laplante Fabrice Morin Jérôme Leprince Marie-Christine Tonon Denis Richard |
| author_sort | Damien Lanfray |
| collection | DOAJ |
| description | Acyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway. |
| first_indexed | 2024-04-14T07:47:13Z |
| format | Article |
| id | doaj.art-7c4a879be6ee420083064ee58f1f9e6d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:47:13Z |
| publishDate | 2016-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
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| spelling | doaj.art-7c4a879be6ee420083064ee58f1f9e6d2022-12-22T02:05:18ZengeLife Sciences Publications LtdeLife2050-084X2016-02-01510.7554/eLife.11742Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in miceDamien Lanfray0https://orcid.org/0000-0002-3326-9896Alexandre Caron1https://orcid.org/0000-0001-6939-6136Marie-Claude Roy2Mathieu Laplante3Fabrice Morin4Jérôme Leprince5Marie-Christine Tonon6Denis Richard7Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, CanadaCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, CanadaCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, CanadaCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, CanadaLaboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut National de la Santé et de la Recherche Médicale, Mont-Saint-Aignan, France; Institute for Research and Innovation in Biomedicine, Normandy University, Mont-Saint-Aignan, FranceLaboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut National de la Santé et de la Recherche Médicale, Mont-Saint-Aignan, France; Institute for Research and Innovation in Biomedicine, Normandy University, Mont-Saint-Aignan, FranceLaboratory of Neuronal and Neuroendocrine Differentiation and Communication, Institut National de la Santé et de la Recherche Médicale, Mont-Saint-Aignan, France; Institute for Research and Innovation in Biomedicine, Normandy University, Mont-Saint-Aignan, FranceCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, CanadaAcyl-CoA binding domain-containing 7 (Acbd7) is a paralog gene of the diazepam-binding inhibitor/Acyl-CoA binding protein in which single nucleotide polymorphism has recently been associated with obesity in humans. In this report, we provide converging evidence indicating that a splice variant isoform of the Acbd7 mRNA is expressed and translated by some POMC and GABAergic-neurons in the hypothalamic arcuate nucleus (ARC). We have demonstrated that the ARC ACBD7 isoform was produced and processed into a bioactive peptide referred to as nonadecaneuropeptide (NDN) in response to catabolic signals. We have characterized NDN as a potent anorexigenic signal acting through an uncharacterized endozepine G protein-coupled receptor and subsequently via the melanocortin system. Our results suggest that ACBD7-producing neurons participate in the hypothalamic leptin signalling pathway. Taken together, these data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.https://elifesciences.org/articles/11742arcuate nucleushypothalamusleptin signalingmelanocortin system |
| spellingShingle | Damien Lanfray Alexandre Caron Marie-Claude Roy Mathieu Laplante Fabrice Morin Jérôme Leprince Marie-Christine Tonon Denis Richard Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice eLife arcuate nucleus hypothalamus leptin signaling melanocortin system |
| title | Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice |
| title_full | Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice |
| title_fullStr | Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice |
| title_full_unstemmed | Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice |
| title_short | Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice |
| title_sort | involvement of the acyl coa binding domain containing 7 in the control of food intake and energy expenditure in mice |
| topic | arcuate nucleus hypothalamus leptin signaling melanocortin system |
| url | https://elifesciences.org/articles/11742 |
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