4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway

4-Methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene, a Major Active Metabolite of Bisphenol A, Triggers Pancreatic β-Cell Death via a JNK/AMPKα Activation-Regulated Endoplasmic Reticulum Stress-Mediated Apoptotic Pathway

4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP), a major active metabolite of bisphenol A (BPA), is generated in the mammalian liver. Some studies have suggested that MBP exerts greater toxicity than BPA. However, the mechanism underlying MBP-induced pancreatic β-cell cytotoxicity remains largely...

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Bibliographic Details
Main Authors: Cheng-Chin Huang, Ching-Yao Yang, Chin-Chuan Su, Kai-Min Fang, Cheng-Chieh Yen, Ching-Ting Lin, Jui-Min Liu, Kuan-I Lee, Ya-Wen Chen, Shing-Hwa Liu, Chun-Fa Huang
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene (MBP)
β-cells
apoptosis
ER stress
JNK
AMPKα
Online Access:https://www.mdpi.com/1422-0067/22/9/4379

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