CD47 Blockade Accelerates Blood Clearance and Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage

CD47 Blockade Accelerates Blood Clearance and Alleviates Early Brain Injury After Experimental Subarachnoid Hemorrhage

AimsSubarachnoid hemorrhage (SAH) is a devastating stroke subtype. Following SAH, erythrocyte lysis contributes to cell death and brain injuries. Blockage of the anti-phagocytic receptor Cluster of Differentiation 47 (CD47) enhances phagocyte clearance of erythrocytes, though it has not been well-st...

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Bibliographic Details
Main Authors: Chao-ran Xu, Jian-ru Li, Shao-wei Jiang, Liang Wan, Xin Zhang, Lei Xia, Xu-ming Hua, Shi-ting Li, Huai-jun Chen, Xiong-jie Fu, Chao-hui Jing
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
subarachnoid hemorrhage
erythrocytes
microglia
neuroinflammation
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.823999/full

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