Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging
For this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors and elasticity-related factors. UVB irradiation induced wrinkle formation, dehyd...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/11/685 |
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| author | Jeongjin Park Dakyung Kim Minhee Lee Sangshin Han Woojin Jun Hyun Mook Jung Yean Kyoung Koo Gwi Hwan Na Sang Hun Han Jehee Han Ok-Kyung Kim |
| author_facet | Jeongjin Park Dakyung Kim Minhee Lee Sangshin Han Woojin Jun Hyun Mook Jung Yean Kyoung Koo Gwi Hwan Na Sang Hun Han Jehee Han Ok-Kyung Kim |
| author_sort | Jeongjin Park |
| collection | DOAJ |
| description | For this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors and elasticity-related factors. UVB irradiation induced wrinkle formation, dehydration, oxidative stress, and inflammation in the dorsal skin of mice; however, these were suppressed in the CV-supplemented groups in UVB-irradiated hairless mice. Furthermore, in UVB-irradiated keratinocytes, CV treatment increased the antioxidant enzyme activities and the levels of sphingomyelin and hyaluronic acid and decreased the production of pro-inflammatory cytokines and the expression of IkB-α and p65 phosphorylation. These findings indicate that CV can directly protect keratinocytes against UVB irradiation-induced oxidative stress and inflammation. Therefore, we suggest that CV can protect against UVB-induced skin photoaging. Therefore, we suggest that caviar is effective for skin health by preventing UVB-induced skin photoaging. |
| first_indexed | 2024-03-09T18:53:51Z |
| format | Article |
| id | doaj.art-7c4bc474de3c49b2893192c3db4d45bb |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T18:53:51Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-7c4bc474de3c49b2893192c3db4d45bb2023-11-24T05:34:25ZengMDPI AGMarine Drugs1660-33972022-10-01201168510.3390/md20110685Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin PhotoagingJeongjin Park0Dakyung Kim1Minhee Lee2Sangshin Han3Woojin Jun4Hyun Mook Jung5Yean Kyoung Koo6Gwi Hwan Na7Sang Hun Han8Jehee Han9Ok-Kyung Kim10Division of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, KoreaDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, KoreaDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, KoreaDepartment of Medical Nutrition, Kyung Hee University, Yongin 17104, KoreaDivision of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, KoreaCosmaxbio, Seongnam-si 13486, KoreaCosmaxbio, Seongnam-si 13486, KoreaCosmaxbio, Seongnam-si 13486, KoreaAlmas Caviar, Hwaseong-si 18553, KoreaAlmas Caviar, Hwaseong-si 18553, KoreaDivision of Food and Nutrition and Human Ecology Research Institute, Chonnam National University, Gwangju 61186, KoreaFor this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors and elasticity-related factors. UVB irradiation induced wrinkle formation, dehydration, oxidative stress, and inflammation in the dorsal skin of mice; however, these were suppressed in the CV-supplemented groups in UVB-irradiated hairless mice. Furthermore, in UVB-irradiated keratinocytes, CV treatment increased the antioxidant enzyme activities and the levels of sphingomyelin and hyaluronic acid and decreased the production of pro-inflammatory cytokines and the expression of IkB-α and p65 phosphorylation. These findings indicate that CV can directly protect keratinocytes against UVB irradiation-induced oxidative stress and inflammation. Therefore, we suggest that CV can protect against UVB-induced skin photoaging. Therefore, we suggest that caviar is effective for skin health by preventing UVB-induced skin photoaging.https://www.mdpi.com/1660-3397/20/11/685caviarUVBoxidative stressskin photoaging |
| spellingShingle | Jeongjin Park Dakyung Kim Minhee Lee Sangshin Han Woojin Jun Hyun Mook Jung Yean Kyoung Koo Gwi Hwan Na Sang Hun Han Jehee Han Ok-Kyung Kim Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging Marine Drugs caviar UVB oxidative stress skin photoaging |
| title | Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging |
| title_full | Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging |
| title_fullStr | Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging |
| title_full_unstemmed | Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging |
| title_short | Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging |
| title_sort | enzyme treated caviar prevents uvb irradiation induced skin photoaging |
| topic | caviar UVB oxidative stress skin photoaging |
| url | https://www.mdpi.com/1660-3397/20/11/685 |
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