Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study
The use of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements is increasingly common among middle-aged and older adults. Users of ω-3 PUFA supplements often report using such supplements to support cognitive health, despite mixed findings reported within the ω-3 PUFA literature. To date, very...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/9/2198 |
| _version_ | 1797602008939626496 |
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| author | Andrew Pipingas Jeffery Michael Reddan Sarah Gauci Lauren M. Young Greg Kennedy Renee Rowsell Rebecca King Sam Spiteri Anne Marie Minihane Andrew Scholey |
| author_facet | Andrew Pipingas Jeffery Michael Reddan Sarah Gauci Lauren M. Young Greg Kennedy Renee Rowsell Rebecca King Sam Spiteri Anne Marie Minihane Andrew Scholey |
| author_sort | Andrew Pipingas |
| collection | DOAJ |
| description | The use of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements is increasingly common among middle-aged and older adults. Users of ω-3 PUFA supplements often report using such supplements to support cognitive health, despite mixed findings reported within the ω-3 PUFA literature. To date, very few studies have explored cognitive effects in distinctly middle-aged (40 to 60 years) adults, and none have examined the acute effects (in the hours following a single dose) on cognitive performance. The current study evaluated whether a single dose of ω-3 PUFA (4020 mg docosahexaenoic acid and 720 mg eicosapentaenoic acid) influences cognitive performance and cardiovascular function in middle-aged males. Cognitive performance and cardiovascular function were assessed before and 3.5–4 h after consumption of a high dose of ω-3 PUFA (DHA + EPA) or placebo, incorporated into a standardized meal (i.e., single serve of Greek yogurt). In this study of middle-aged males, no significant differential treatment effects were observed for cognitive performance. However, a significant reduction in aortic systolic blood pressure (pre-dose to post-dose) was apparent following consumption of the ω-3 PUFA (DHA + EPA) treatment (mean difference = −4.11 mmHg, <i>p</i> = 0.004) but not placebo (mean difference = −1.39 mmHg, <i>p</i> = 0.122). Future replication in a sample comprising females, as well as patients with hypertension, is merited. |
| first_indexed | 2024-03-11T04:10:08Z |
| format | Article |
| id | doaj.art-7c4db44475904195bbc205a03771c9f3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T04:10:08Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-7c4db44475904195bbc205a03771c9f32023-11-17T23:30:29ZengMDPI AGNutrients2072-66432023-05-01159219810.3390/nu15092198Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot StudyAndrew Pipingas0Jeffery Michael Reddan1Sarah Gauci2Lauren M. Young3Greg Kennedy4Renee Rowsell5Rebecca King6Sam Spiteri7Anne Marie Minihane8Andrew Scholey9Centre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaFood & Mood Centre, The Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, VIC 3220, AustraliaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaNorwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UKCentre for Mental Health and Brain Sciences, Swinburne University of Technology, Hawthorn, VIC 3122, AustraliaThe use of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplements is increasingly common among middle-aged and older adults. Users of ω-3 PUFA supplements often report using such supplements to support cognitive health, despite mixed findings reported within the ω-3 PUFA literature. To date, very few studies have explored cognitive effects in distinctly middle-aged (40 to 60 years) adults, and none have examined the acute effects (in the hours following a single dose) on cognitive performance. The current study evaluated whether a single dose of ω-3 PUFA (4020 mg docosahexaenoic acid and 720 mg eicosapentaenoic acid) influences cognitive performance and cardiovascular function in middle-aged males. Cognitive performance and cardiovascular function were assessed before and 3.5–4 h after consumption of a high dose of ω-3 PUFA (DHA + EPA) or placebo, incorporated into a standardized meal (i.e., single serve of Greek yogurt). In this study of middle-aged males, no significant differential treatment effects were observed for cognitive performance. However, a significant reduction in aortic systolic blood pressure (pre-dose to post-dose) was apparent following consumption of the ω-3 PUFA (DHA + EPA) treatment (mean difference = −4.11 mmHg, <i>p</i> = 0.004) but not placebo (mean difference = −1.39 mmHg, <i>p</i> = 0.122). Future replication in a sample comprising females, as well as patients with hypertension, is merited.https://www.mdpi.com/2072-6643/15/9/2198omega-3 PUFADHAnootropicmiddle-agedacutecognition |
| spellingShingle | Andrew Pipingas Jeffery Michael Reddan Sarah Gauci Lauren M. Young Greg Kennedy Renee Rowsell Rebecca King Sam Spiteri Anne Marie Minihane Andrew Scholey Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study Nutrients omega-3 PUFA DHA nootropic middle-aged acute cognition |
| title | Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study |
| title_full | Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study |
| title_fullStr | Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study |
| title_full_unstemmed | Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study |
| title_short | Post-Prandial Cognitive and Blood Pressure Effects of a DHA-Rich Omega-3 Powder in Middle-Aged Males: A Pilot Study |
| title_sort | post prandial cognitive and blood pressure effects of a dha rich omega 3 powder in middle aged males a pilot study |
| topic | omega-3 PUFA DHA nootropic middle-aged acute cognition |
| url | https://www.mdpi.com/2072-6643/15/9/2198 |
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