Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications
A fine control over different dimensional scales is a challenging target for material science since it could grant control over many properties of the final material. In this study, we developed a multivariable additive manufacturing process, direct ink write printing, to control different architect...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/2/83 |
| _version_ | 1797485833669836800 |
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| author | Devis Montroni Takeru Kobayashi Taige Hao Derek Lublin Tomoko Yoshino David Kisailus |
| author_facet | Devis Montroni Takeru Kobayashi Taige Hao Derek Lublin Tomoko Yoshino David Kisailus |
| author_sort | Devis Montroni |
| collection | DOAJ |
| description | A fine control over different dimensional scales is a challenging target for material science since it could grant control over many properties of the final material. In this study, we developed a multivariable additive manufacturing process, direct ink write printing, to control different architectural features from the nano- to the millimeter scale during extrusion. Chitin-based gel fibers with a water content of around 1500% were obtained extruding a polymeric solution of chitin into a counter solvent, water, inducing instant solidification of the material. A certain degree of fibrillar alignment was achieved basing on the shear stress induced by the nozzle. In this study we took into account a single variable, the nozzle’s internal diameter (NID). In fact, a positive correlation between NID, fibril alignment, and mechanical resistance was observed. A negative correlation with NID was observed with porosity, exposed surface, and lightly with water content. No correlation was observed with maximum elongation (~50%), and the scaffold’s excellent biocompatibility, which appeared unaltered. Overall, a single variable allowed a customization of different material features, which could be further tuned, adding control over other aspects of the synthetic process. Moreover, this manufacturing could be potentially applied to any polymer. |
| first_indexed | 2024-03-09T23:25:27Z |
| format | Article |
| id | doaj.art-7c4ed80ca93a4e02a8514cb5b555553b |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T23:25:27Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-7c4ed80ca93a4e02a8514cb5b555553b2023-11-23T17:19:56ZengMDPI AGJournal of Functional Biomaterials2079-49832022-06-011328310.3390/jfb13020083Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical ApplicationsDevis Montroni0Takeru Kobayashi1Taige Hao2Derek Lublin3Tomoko Yoshino4David Kisailus5Department of Materials Science and Engineering, University of California at Irvine, Irvine, CA 92697, USADepartment of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei 184-8588, Tokyo, JapanDepartment of Materials Science and Engineering, University of California at Irvine, Irvine, CA 92697, USAMaterials and Manufacturing Technology Program, School of Engineering, University of California at Irvine, Irvine, CA 92697, USADepartment of Biotechnology, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei 184-8588, Tokyo, JapanDepartment of Materials Science and Engineering, University of California at Irvine, Irvine, CA 92697, USAA fine control over different dimensional scales is a challenging target for material science since it could grant control over many properties of the final material. In this study, we developed a multivariable additive manufacturing process, direct ink write printing, to control different architectural features from the nano- to the millimeter scale during extrusion. Chitin-based gel fibers with a water content of around 1500% were obtained extruding a polymeric solution of chitin into a counter solvent, water, inducing instant solidification of the material. A certain degree of fibrillar alignment was achieved basing on the shear stress induced by the nozzle. In this study we took into account a single variable, the nozzle’s internal diameter (NID). In fact, a positive correlation between NID, fibril alignment, and mechanical resistance was observed. A negative correlation with NID was observed with porosity, exposed surface, and lightly with water content. No correlation was observed with maximum elongation (~50%), and the scaffold’s excellent biocompatibility, which appeared unaltered. Overall, a single variable allowed a customization of different material features, which could be further tuned, adding control over other aspects of the synthetic process. Moreover, this manufacturing could be potentially applied to any polymer.https://www.mdpi.com/2079-4983/13/2/83polysaccharidebiopolymerdirect ink write printingadditive manufacturingporousbiocompatible |
| spellingShingle | Devis Montroni Takeru Kobayashi Taige Hao Derek Lublin Tomoko Yoshino David Kisailus Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications Journal of Functional Biomaterials polysaccharide biopolymer direct ink write printing additive manufacturing porous biocompatible |
| title | Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications |
| title_full | Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications |
| title_fullStr | Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications |
| title_full_unstemmed | Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications |
| title_short | Direct Ink Write Printing of Chitin-Based Gel Fibers with Customizable Fibril Alignment, Porosity, and Mechanical Properties for Biomedical Applications |
| title_sort | direct ink write printing of chitin based gel fibers with customizable fibril alignment porosity and mechanical properties for biomedical applications |
| topic | polysaccharide biopolymer direct ink write printing additive manufacturing porous biocompatible |
| url | https://www.mdpi.com/2079-4983/13/2/83 |
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