Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice
Abstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-ter...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94594-7 |
| _version_ | 1818723106828582912 |
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| author | Le Su Yue Su Zaiyong An Ping Zhang Qiulin Yue Chen Zhao Xin Sun Song Zhang Xinli Liu Kunlun Li Lin Zhao |
| author_facet | Le Su Yue Su Zaiyong An Ping Zhang Qiulin Yue Chen Zhao Xin Sun Song Zhang Xinli Liu Kunlun Li Lin Zhao |
| author_sort | Le Su |
| collection | DOAJ |
| description | Abstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-term used medicine for UC cure. Recently, the Chinese traditional herb Danshen has been investigated in the treatment of UC. However, it is a limitation of Danshen that many of the active components in Danshen are not easily absorbed by the human body. Probiotics could convert macromolecules into smaller molecules to facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) and Bacillus subtillis Natto (F-A7-1) were screened to ferment Danshen in this study. The fermented Danshen products were gavaged in the dextran sulfate sodium (DSS)-induced UC model mice. Danshen had better results to attenuate symptoms of DSS-induced UC after fermented with F-B4-1 and F-A7-1. Loss of body weight and disease activity index (DAI) were reduced. The abnormally short colon lengths and colonic damage were recovered. And fermented Danshen had the better inhibitory effect than Danshen itself on pro-inflammatory cytokine expression during DSS-induced UC. The results indicated that compared with Danshen, fermented Danshen relieved DSS-induced UC in mice more effectively. Danshen fermented by probiotics might be an effective treatment to UC in clinic stage in the future. |
| first_indexed | 2024-12-17T21:05:15Z |
| format | Article |
| id | doaj.art-7c4f73bbf760432ebcc479e5adc11147 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T21:05:15Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7c4f73bbf760432ebcc479e5adc111472022-12-21T21:32:35ZengNature PortfolioScientific Reports2045-23222021-08-0111111310.1038/s41598-021-94594-7Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in miceLe Su0Yue Su1Zaiyong An2Ping Zhang3Qiulin Yue4Chen Zhao5Xin Sun6Song Zhang7Xinli Liu8Kunlun Li9Lin Zhao10State Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesShandong Provincial Key Laboratory of Food and Fermentation Engineering, Shandong Food Ferment Industry Research and Design Institute, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesJinan Hangchen Biotechnology Co., Ltd.State Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of SciencesAbstract With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-term used medicine for UC cure. Recently, the Chinese traditional herb Danshen has been investigated in the treatment of UC. However, it is a limitation of Danshen that many of the active components in Danshen are not easily absorbed by the human body. Probiotics could convert macromolecules into smaller molecules to facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) and Bacillus subtillis Natto (F-A7-1) were screened to ferment Danshen in this study. The fermented Danshen products were gavaged in the dextran sulfate sodium (DSS)-induced UC model mice. Danshen had better results to attenuate symptoms of DSS-induced UC after fermented with F-B4-1 and F-A7-1. Loss of body weight and disease activity index (DAI) were reduced. The abnormally short colon lengths and colonic damage were recovered. And fermented Danshen had the better inhibitory effect than Danshen itself on pro-inflammatory cytokine expression during DSS-induced UC. The results indicated that compared with Danshen, fermented Danshen relieved DSS-induced UC in mice more effectively. Danshen fermented by probiotics might be an effective treatment to UC in clinic stage in the future.https://doi.org/10.1038/s41598-021-94594-7 |
| spellingShingle | Le Su Yue Su Zaiyong An Ping Zhang Qiulin Yue Chen Zhao Xin Sun Song Zhang Xinli Liu Kunlun Li Lin Zhao Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice Scientific Reports |
| title | Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice |
| title_full | Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice |
| title_fullStr | Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice |
| title_full_unstemmed | Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice |
| title_short | Fermentation products of Danshen relieved dextran sulfate sodium-induced experimental ulcerative colitis in mice |
| title_sort | fermentation products of danshen relieved dextran sulfate sodium induced experimental ulcerative colitis in mice |
| url | https://doi.org/10.1038/s41598-021-94594-7 |
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