The use of GnRH analogs in preserving ovarian function during chemotherapy
Abstract Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-11-01
|
| Series: | Middle East Fertility Society Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43043-021-00088-x |
| _version_ | 1819015128504336384 |
|---|---|
| author | Omar M. Odeh Johnny Awwad Dalia Khalife Suleiman Ghunaim |
| author_facet | Omar M. Odeh Johnny Awwad Dalia Khalife Suleiman Ghunaim |
| author_sort | Omar M. Odeh |
| collection | DOAJ |
| description | Abstract Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When it comes to preserving fertility, it is crucial to consider all available options in this topic due to its very sensitive nature, thereby we have found that while a lot of trials favor the use of gonadotropin-releasing hormone agonists, the lack of proper follow-up and long-term trials renders its use highly debatable, and since the longest follow-up trial showed non-significant results, it also opens the floor for debate on whether this short-term benefit is worth adding another drug to the regimen or not. Short conclusion As described in this review, while the use of gonadotropin-releasing hormone agonists is beneficial in a lot of studies, the lack of long-term reports still makes its use debatable, thereby more trials should be done. |
| first_indexed | 2024-12-21T02:26:49Z |
| format | Article |
| id | doaj.art-7c4fe4d711f4490d89062e414857118b |
| institution | Directory Open Access Journal |
| issn | 2090-3251 |
| language | English |
| last_indexed | 2024-12-21T02:26:49Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-7c4fe4d711f4490d89062e414857118b2022-12-21T19:19:01ZengSpringerOpenMiddle East Fertility Society Journal2090-32512021-11-0126111110.1186/s43043-021-00088-xThe use of GnRH analogs in preserving ovarian function during chemotherapyOmar M. Odeh0Johnny Awwad1Dalia Khalife2Suleiman Ghunaim3School of Medicine, The University of JordanDepartment of Obstetrics and Gynecology, Faculty of Medicine, American University of BeirutDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Haifa Idriss-ART Unit, American University of BeirutDepartment of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Haifa Idriss-ART Unit, American University of BeirutAbstract Background The literature has always been controversial on the use of gonadotropin-releasing hormone agonists in preserving fertility in women of childbearing age after chemotherapy; thereby, in this article, we will be discussing its use in preserving fertility. Main body of abstract When it comes to preserving fertility, it is crucial to consider all available options in this topic due to its very sensitive nature, thereby we have found that while a lot of trials favor the use of gonadotropin-releasing hormone agonists, the lack of proper follow-up and long-term trials renders its use highly debatable, and since the longest follow-up trial showed non-significant results, it also opens the floor for debate on whether this short-term benefit is worth adding another drug to the regimen or not. Short conclusion As described in this review, while the use of gonadotropin-releasing hormone agonists is beneficial in a lot of studies, the lack of long-term reports still makes its use debatable, thereby more trials should be done.https://doi.org/10.1186/s43043-021-00088-xGnRH agonistsFertilityChemotherapy |
| spellingShingle | Omar M. Odeh Johnny Awwad Dalia Khalife Suleiman Ghunaim The use of GnRH analogs in preserving ovarian function during chemotherapy Middle East Fertility Society Journal GnRH agonists Fertility Chemotherapy |
| title | The use of GnRH analogs in preserving ovarian function during chemotherapy |
| title_full | The use of GnRH analogs in preserving ovarian function during chemotherapy |
| title_fullStr | The use of GnRH analogs in preserving ovarian function during chemotherapy |
| title_full_unstemmed | The use of GnRH analogs in preserving ovarian function during chemotherapy |
| title_short | The use of GnRH analogs in preserving ovarian function during chemotherapy |
| title_sort | use of gnrh analogs in preserving ovarian function during chemotherapy |
| topic | GnRH agonists Fertility Chemotherapy |
| url | https://doi.org/10.1186/s43043-021-00088-x |
| work_keys_str_mv | AT omarmodeh theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT johnnyawwad theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT daliakhalife theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT suleimanghunaim theuseofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT omarmodeh useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT johnnyawwad useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT daliakhalife useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy AT suleimanghunaim useofgnrhanalogsinpreservingovarianfunctionduringchemotherapy |