Viral manipulation of the cellular sumoylation machinery
Abstract Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has emerged as an important post-translational modification that is manipulated by virus...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-07-01
|
| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12964-017-0183-0 |
| _version_ | 1818387592119320576 |
|---|---|
| author | Angela J. Lowrey Wyatt Cramblet Gretchen L. Bentz |
| author_facet | Angela J. Lowrey Wyatt Cramblet Gretchen L. Bentz |
| author_sort | Angela J. Lowrey |
| collection | DOAJ |
| description | Abstract Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has emerged as an important post-translational modification that is manipulated by viruses to modulate anti-viral responses, viral replication, and viral pathogenesis. The process of sumoylation is a multi-step cascade where a small ubiquitin-like modifier (SUMO) is covalently attached to a conserved ΨKxD/E motif within a target protein, altering the function of the modified protein. Here we review how viruses manipulate the cellular machinery at each step of the sumoylation process to favor viral survival and pathogenesis. |
| first_indexed | 2024-12-14T04:12:23Z |
| format | Article |
| id | doaj.art-7c50dd33c7cb4106a9147741e94e364b |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-14T04:12:23Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-7c50dd33c7cb4106a9147741e94e364b2022-12-21T23:17:37ZengBMCCell Communication and Signaling1478-811X2017-07-0115111410.1186/s12964-017-0183-0Viral manipulation of the cellular sumoylation machineryAngela J. Lowrey0Wyatt Cramblet1Gretchen L. Bentz2Division of Biomedical Sciences, Mercer University School of MedicineDivision of Biomedical Sciences, Mercer University School of MedicineDivision of Biomedical Sciences, Mercer University School of MedicineAbstract Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has emerged as an important post-translational modification that is manipulated by viruses to modulate anti-viral responses, viral replication, and viral pathogenesis. The process of sumoylation is a multi-step cascade where a small ubiquitin-like modifier (SUMO) is covalently attached to a conserved ΨKxD/E motif within a target protein, altering the function of the modified protein. Here we review how viruses manipulate the cellular machinery at each step of the sumoylation process to favor viral survival and pathogenesis.http://link.springer.com/article/10.1186/s12964-017-0183-0VirusesSmall ubiquitin-like modifierSumoUbc9SenpPias |
| spellingShingle | Angela J. Lowrey Wyatt Cramblet Gretchen L. Bentz Viral manipulation of the cellular sumoylation machinery Cell Communication and Signaling Viruses Small ubiquitin-like modifier Sumo Ubc9 Senp Pias |
| title | Viral manipulation of the cellular sumoylation machinery |
| title_full | Viral manipulation of the cellular sumoylation machinery |
| title_fullStr | Viral manipulation of the cellular sumoylation machinery |
| title_full_unstemmed | Viral manipulation of the cellular sumoylation machinery |
| title_short | Viral manipulation of the cellular sumoylation machinery |
| title_sort | viral manipulation of the cellular sumoylation machinery |
| topic | Viruses Small ubiquitin-like modifier Sumo Ubc9 Senp Pias |
| url | http://link.springer.com/article/10.1186/s12964-017-0183-0 |
| work_keys_str_mv | AT angelajlowrey viralmanipulationofthecellularsumoylationmachinery AT wyattcramblet viralmanipulationofthecellularsumoylationmachinery AT gretchenlbentz viralmanipulationofthecellularsumoylationmachinery |