JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2

JMJD1A/NR4A1 Signaling Regulates the Procession of Renal Tubular Epithelial Interstitial Fibrosis Induced by AGEs in HK-2

Diabetic kidney disease (DKD) is one of the most serious complications of diabetic patients. Advanced glycation end products (AGEs) induce epithelial-mesenchymal transformation (EMT) of renal tubular epithelial cells (HK-2), resulting in renal tubulointerstitial fibrosis. However, the underlying epi...

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Bibliographic Details
Main Authors: Shaoting Wang, Anna Zuo, Weiqiang Jiang, Jiarun Xie, Haoyu Lin, Wei Sun, Min Zhao, Jinjin Xia, Junqiao Shao, Xiaoshan Zhao, Donghui Liang, Aicheng Yang, Jia Sun, Ming Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Medicine
Subjects:
diabetic kidney disease
renal fibrosis
epigenetics
JMJD1A
NR4A1
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.807694/full

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