Modeling and simulation of procoagulant circulating tumor cells in flow

Modeling and simulation of procoagulant circulating tumor cells in flow

We describe a mathematical/computational model for thrombin concentration gradients generated by procoagulant circulating tumor cells (CTCs) in flow. We examine how CTCs enhance blood coagulation as they diffuse tissue factor (TF)-dependent coagulation enzymes in a flow environment with vessel walls...

Full description

Bibliographic Details
Main Authors: Angela eLee, Garth William Tormoen, Eva eKanso, Owen eMcCarty, Paul Kenneth Newton
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Oncology
Subjects:
circulating tumor cells
procoagulant circulating tumor cells
chemical gradient tracking
tissue factor and coagulation
prothrombin and thrombin fields
circulating tumor cell induced hypercoagulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00108/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00108/full

Similar Items