Induction of Type 1, 2 and 3 Interferons by Acridone Acetates
The induction profile of endogenous interferons of three types under the action of meglumine acridone acetate and sodium acridone acetate, as well as the characteristics of the kinetics of their accumulation and circulation in the blood of experimental animals are described. Meglumine acridone aceta...
| প্রধান লেখক: | , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | Russian |
| প্রকাশিত: |
LLC "Publishing House OKI"
2020-05-01
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| মালা: | Антибиотики и Химиотерапия |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://www.antibiotics-chemotherapy.ru/jour/article/view/562 |
| _version_ | 1826573489280122880 |
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| author | S. S. Grigoryan A. Yu. Petrov E. I. Isaeva M. A. Muzykin A. L. Kovalenko M. G. Romantsov |
| author_facet | S. S. Grigoryan A. Yu. Petrov E. I. Isaeva M. A. Muzykin A. L. Kovalenko M. G. Romantsov |
| author_sort | S. S. Grigoryan |
| collection | DOAJ |
| description | The induction profile of endogenous interferons of three types under the action of meglumine acridone acetate and sodium acridone acetate, as well as the characteristics of the kinetics of their accumulation and circulation in the blood of experimental animals are described. Meglumine acridone acetate provided balance in induction, production and circulation of the interferons in the blood vs. sodium acridone acetate under the same conditions. The optimal dose of meglumine acridone acetate (2.0-3.5 mg/mouse) with effective, consecutive and overlapping induction-production of the interferons ensured their prolonged (for 72 hours) circulation in the blood after a single administration. |
| first_indexed | 2025-03-14T12:43:43Z |
| format | Article |
| id | doaj.art-7c55ec980d884e57b6742751830a5617 |
| institution | Directory Open Access Journal |
| issn | 0235-2990 |
| language | Russian |
| last_indexed | 2025-03-14T12:43:43Z |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj.art-7c55ec980d884e57b6742751830a56172025-03-02T09:09:18ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01599-1039561Induction of Type 1, 2 and 3 Interferons by Acridone AcetatesS. S. Grigoryan0A. Yu. Petrov1E. I. Isaeva2M. A. Muzykin3A. L. Kovalenko4M. G. Romantsov5N. F. Gamaleya Research Institute of Epidemiology and MicrobiologyPOLYSAN CoN. F. Gamaleya Research Institute of Epidemiology and MicrobiologyPOLYSAN CoInstitute of Toxicology of Federal Medico-Biological AgencyI. I. Mechnikov North-Western State Medical UniversityThe induction profile of endogenous interferons of three types under the action of meglumine acridone acetate and sodium acridone acetate, as well as the characteristics of the kinetics of their accumulation and circulation in the blood of experimental animals are described. Meglumine acridone acetate provided balance in induction, production and circulation of the interferons in the blood vs. sodium acridone acetate under the same conditions. The optimal dose of meglumine acridone acetate (2.0-3.5 mg/mouse) with effective, consecutive and overlapping induction-production of the interferons ensured their prolonged (for 72 hours) circulation in the blood after a single administration.https://www.antibiotics-chemotherapy.ru/jour/article/view/562acridone acetic acidinterferons (alphagamma and lambda)meglumine acridone acetate (cycloferon)-гамма и -лямбда |
| spellingShingle | S. S. Grigoryan A. Yu. Petrov E. I. Isaeva M. A. Muzykin A. L. Kovalenko M. G. Romantsov Induction of Type 1, 2 and 3 Interferons by Acridone Acetates Антибиотики и Химиотерапия acridone acetic acid interferons (alpha gamma and lambda) meglumine acridone acetate (cycloferon) -гамма и -лямбда |
| title | Induction of Type 1, 2 and 3 Interferons by Acridone Acetates |
| title_full | Induction of Type 1, 2 and 3 Interferons by Acridone Acetates |
| title_fullStr | Induction of Type 1, 2 and 3 Interferons by Acridone Acetates |
| title_full_unstemmed | Induction of Type 1, 2 and 3 Interferons by Acridone Acetates |
| title_short | Induction of Type 1, 2 and 3 Interferons by Acridone Acetates |
| title_sort | induction of type 1 2 and 3 interferons by acridone acetates |
| topic | acridone acetic acid interferons (alpha gamma and lambda) meglumine acridone acetate (cycloferon) -гамма и -лямбда |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/562 |
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