Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

Functional Coexpression of HSV-1 Thymidine Kinase and Green Fluorescent Protein: Implications for Noninvasive Imaging of Transgene Expression

Current gene therapy technology is limited by the paucity of methodology for determining the location and magnitude of therapeutic transgene expression in vivo. We describe and validate a paradigm for monitoring therapeutic transgene expression by noninvasive imaging of the herpes simplex virus type...

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Bibliographic Details
Main Authors: Andreas Jacobs, Michael Dubrovin, Jeff Hewett, Miguel Sena-Esteves, Cui-Wen Tan, Mark Slack, Michele Sadelain, Xandra O. Breakefield, Juri G. Tjuvajev
Format: Article
Language:English
Published: Elsevier 1999-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
thymidine kinase
ganciclovir
FIAU
cancer gene therapy
fusion genes
imaging
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800566

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