Chiral Systems Made from DNA
Abstract The very chemical structure of DNA that enables biological heredity and evolution has non‐trivial implications for the self‐organization of DNA molecules into larger assemblies and provides limitless opportunities for building functional nanostructures. This progress report discusses the na...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202003113 |
| _version_ | 1818444073707503616 |
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| author | David Winogradoff Pin‐Yi Li Himanshu Joshi Lauren Quednau Christopher Maffeo Aleksei Aksimentiev |
| author_facet | David Winogradoff Pin‐Yi Li Himanshu Joshi Lauren Quednau Christopher Maffeo Aleksei Aksimentiev |
| author_sort | David Winogradoff |
| collection | DOAJ |
| description | Abstract The very chemical structure of DNA that enables biological heredity and evolution has non‐trivial implications for the self‐organization of DNA molecules into larger assemblies and provides limitless opportunities for building functional nanostructures. This progress report discusses the natural organization of DNA into chiral structures and recent advances in creating synthetic chiral systems using DNA as a building material. How nucleic acid chirality naturally comes into play in a diverse array of situations is considered first, at length scales ranging from an individual nucleotide to entire chromosomes. Thereafter, chiral liquid crystal phases formed by dense DNA mixtures are discussed, including the ongoing efforts to understand their origins. The report then summarizes recent efforts directed toward building chiral structures, and other structures of complex topology, using the principle of DNA self‐assembly. Discussed last are existing and proposed functional man‐made nanostructures designed to either probe or harness DNA's chirality, from plasmonics and spintronics to biosensing. |
| first_indexed | 2024-12-14T19:10:08Z |
| format | Article |
| id | doaj.art-7c5700787a2349a796bae1379d40f79f |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-14T19:10:08Z |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-7c5700787a2349a796bae1379d40f79f2022-12-21T22:50:44ZengWileyAdvanced Science2198-38442021-03-0185n/an/a10.1002/advs.202003113Chiral Systems Made from DNADavid Winogradoff0Pin‐Yi Li1Himanshu Joshi2Lauren Quednau3Christopher Maffeo4Aleksei Aksimentiev5Center for the Physics of Living Cells University of Illinois at Urbana–Champaign Urbana IL USADepartment of Physics University of Illinois at Urbana–Champaign Urbana IL USADepartment of Physics University of Illinois at Urbana–Champaign Urbana IL USACenter for the Physics of Living Cells University of Illinois at Urbana–Champaign Urbana IL USACenter for the Physics of Living Cells University of Illinois at Urbana–Champaign Urbana IL USACenter for the Physics of Living Cells University of Illinois at Urbana–Champaign Urbana IL USAAbstract The very chemical structure of DNA that enables biological heredity and evolution has non‐trivial implications for the self‐organization of DNA molecules into larger assemblies and provides limitless opportunities for building functional nanostructures. This progress report discusses the natural organization of DNA into chiral structures and recent advances in creating synthetic chiral systems using DNA as a building material. How nucleic acid chirality naturally comes into play in a diverse array of situations is considered first, at length scales ranging from an individual nucleotide to entire chromosomes. Thereafter, chiral liquid crystal phases formed by dense DNA mixtures are discussed, including the ongoing efforts to understand their origins. The report then summarizes recent efforts directed toward building chiral structures, and other structures of complex topology, using the principle of DNA self‐assembly. Discussed last are existing and proposed functional man‐made nanostructures designed to either probe or harness DNA's chirality, from plasmonics and spintronics to biosensing.https://doi.org/10.1002/advs.202003113DNA origamiliquid crystalsnanotechnologyplasmonicsself‐assembly |
| spellingShingle | David Winogradoff Pin‐Yi Li Himanshu Joshi Lauren Quednau Christopher Maffeo Aleksei Aksimentiev Chiral Systems Made from DNA Advanced Science DNA origami liquid crystals nanotechnology plasmonics self‐assembly |
| title | Chiral Systems Made from DNA |
| title_full | Chiral Systems Made from DNA |
| title_fullStr | Chiral Systems Made from DNA |
| title_full_unstemmed | Chiral Systems Made from DNA |
| title_short | Chiral Systems Made from DNA |
| title_sort | chiral systems made from dna |
| topic | DNA origami liquid crystals nanotechnology plasmonics self‐assembly |
| url | https://doi.org/10.1002/advs.202003113 |
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