Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol
Introduction Hypertension has been considered a contraindication for living kidney donation in the past. Since transplantation from living kidney donors remains the best modality for kidney failure, there is now an increased acceptance of living kidney donors with hypertension. However, the safety o...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/12/e064132.full |
| _version_ | 1797777004968280064 |
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| author | Greg Knoll Risa Shorr Kevin D Burns Swapnil Hiremath Ann Bugeja Mariam Eldaba Sumaiya Ahmed Edward G Clark |
| author_facet | Greg Knoll Risa Shorr Kevin D Burns Swapnil Hiremath Ann Bugeja Mariam Eldaba Sumaiya Ahmed Edward G Clark |
| author_sort | Greg Knoll |
| collection | DOAJ |
| description | Introduction Hypertension has been considered a contraindication for living kidney donation in the past. Since transplantation from living kidney donors remains the best modality for kidney failure, there is now an increased acceptance of living kidney donors with hypertension. However, the safety of this practice for the cardiovascular and kidney health of the donor is unclear. We will conduct a systematic review to summarise and synthesise the existing literature on this topic.Methods and analysis A systematic review of prospective randomised and non-randomised and retrospective studies will be conducted. MEDLINE, EMBASE, Cochrane CENTRAL and EBM reviews published from January 1946 to December 2021 will be reviewed. Primary outcome will be the difference in the survival, major adverse cardiovascular events, estimated glomerular filtration rate of 45 mL/min or less and development of end-stage kidney failure, between living kidney donors with and without hypertension. Study screening, selection, and data extraction will be performed by two independent reviewers. Studies must fulfil all eligibility criteria for inclusion into the systematic review and meta-analysis. The Risk of Bias in Non-Randomised studies tool will be used to assess bias.Ethics and dissemination No ethical approval is required for this systematic review. The results of this review will be disseminated in a peer-reviewed, open-access journal to ensure access to all stakeholders in kidney transplantation and to inform clinical guidelines on the evaluation and follow-up care of living kidney donor candidates.PROSPERO registration number CRD42022300119. |
| first_indexed | 2024-03-12T22:57:54Z |
| format | Article |
| id | doaj.art-7c571aeee7024b3b9d727cf4a2824f34 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-03-12T22:57:54Z |
| publishDate | 2022-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-7c571aeee7024b3b9d727cf4a2824f342023-07-19T17:00:08ZengBMJ Publishing GroupBMJ Open2044-60552022-12-01121210.1136/bmjopen-2022-064132Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocolGreg Knoll0Risa Shorr1Kevin D Burns2Swapnil Hiremath3Ann Bugeja4Mariam Eldaba5Sumaiya Ahmed6Edward G Clark7Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDepartment of Medicine (Neurology), University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDivision of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDivision of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDivision of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaDepartment of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, CanadaDepartment of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, CanadaDivision of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaIntroduction Hypertension has been considered a contraindication for living kidney donation in the past. Since transplantation from living kidney donors remains the best modality for kidney failure, there is now an increased acceptance of living kidney donors with hypertension. However, the safety of this practice for the cardiovascular and kidney health of the donor is unclear. We will conduct a systematic review to summarise and synthesise the existing literature on this topic.Methods and analysis A systematic review of prospective randomised and non-randomised and retrospective studies will be conducted. MEDLINE, EMBASE, Cochrane CENTRAL and EBM reviews published from January 1946 to December 2021 will be reviewed. Primary outcome will be the difference in the survival, major adverse cardiovascular events, estimated glomerular filtration rate of 45 mL/min or less and development of end-stage kidney failure, between living kidney donors with and without hypertension. Study screening, selection, and data extraction will be performed by two independent reviewers. Studies must fulfil all eligibility criteria for inclusion into the systematic review and meta-analysis. The Risk of Bias in Non-Randomised studies tool will be used to assess bias.Ethics and dissemination No ethical approval is required for this systematic review. The results of this review will be disseminated in a peer-reviewed, open-access journal to ensure access to all stakeholders in kidney transplantation and to inform clinical guidelines on the evaluation and follow-up care of living kidney donor candidates.PROSPERO registration number CRD42022300119.https://bmjopen.bmj.com/content/12/12/e064132.full |
| spellingShingle | Greg Knoll Risa Shorr Kevin D Burns Swapnil Hiremath Ann Bugeja Mariam Eldaba Sumaiya Ahmed Edward G Clark Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol BMJ Open |
| title | Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol |
| title_full | Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol |
| title_fullStr | Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol |
| title_full_unstemmed | Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol |
| title_short | Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol |
| title_sort | kidney function cardiovascular outcomes and survival of living kidney donors with hypertension a systematic review protocol |
| url | https://bmjopen.bmj.com/content/12/12/e064132.full |
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