Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16
Fruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit <i>Dipteryx alata</i>; evaluate its toxic effects, influence on the life expectanc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/8/1106 |
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| author | Natasha Rios Leite Laura Costa Alves de Araújo Paola dos Santos da Rocha Danielle Araujo Agarrayua Daiana Silva Ávila Carlos Alexandre Carollo Denise Brentan Silva Leticia Miranda Estevinho Kely de Picoli Souza Edson Lucas dos Santos |
| author_facet | Natasha Rios Leite Laura Costa Alves de Araújo Paola dos Santos da Rocha Danielle Araujo Agarrayua Daiana Silva Ávila Carlos Alexandre Carollo Denise Brentan Silva Leticia Miranda Estevinho Kely de Picoli Souza Edson Lucas dos Santos |
| author_sort | Natasha Rios Leite |
| collection | DOAJ |
| description | Fruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit <i>Dipteryx alata</i>; evaluate its toxic effects, influence on the life expectancy of the nematode <i>Caenorhabditis elegans</i>, and its antioxidant activities in vitro and in vivo; and describe the mechanisms involved. The chemical compounds identified include phenols, terpenes, fatty acid derivatives, vitamins, and a carboxylic acid. The in vitro antioxidant activity was demonstrated by radical scavenging methods. in vivo, the <i>D. alata</i> fruit pulp was not toxic and promoted resistance to oxidative stress in nematodes exposed to a chemical oxidizing agent. Furthermore, it promoted an increased life expectancy in wild-type nematodes and increased the expression of superoxide dismutase and the nuclear translocation of DAF-16. These results suggest that the beneficial effects identified are related to these two genes, which are involved in the regulation of metabolic activities, the control of oxidative stress, and the lifespan <i>of C. elegans</i>. These beneficial effects, which may be related to its chemical constituents, demonstrate its potential use as a functional and/or nutraceutical food. |
| first_indexed | 2024-03-10T18:13:05Z |
| format | Article |
| id | doaj.art-7c59a524c8244af19a0282f9decbd8de |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T18:13:05Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7c59a524c8244af19a0282f9decbd8de2023-11-20T07:56:28ZengMDPI AGBiomolecules2218-273X2020-07-01108110610.3390/biom10081106Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16Natasha Rios Leite0Laura Costa Alves de Araújo1Paola dos Santos da Rocha2Danielle Araujo Agarrayua3Daiana Silva Ávila4Carlos Alexandre Carollo5Denise Brentan Silva6Leticia Miranda Estevinho7Kely de Picoli Souza8Edson Lucas dos Santos9Research group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, BrazilResearch group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, BrazilResearch group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, BrazilResearch Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, BR 472, km 585, Caixa Postal 118, Uruguaiana CEP 97501-970, Rio Grande do Sul, BrazilResearch Group in Biochemistry and Toxicology in Caenorhabditis elegans, Federal University of Pampa, BR 472, km 585, Caixa Postal 118, Uruguaiana CEP 97501-970, Rio Grande do Sul, BrazilLaboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Cidade Universitária, Mato Grosso do Sul CEP 79070-900, BrazilLaboratory of Natural Products and Mass Spectrometry, Federal University of Mato Grosso do Sul, Cidade Universitária, Mato Grosso do Sul CEP 79070-900, BrazilPolytechnic Institute of Bragança, Agricultural College of Bragança, Campus Santa Apolónia, 5301-855 Bragança, PortugalResearch group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, BrazilResearch group on Biotechnology and Bioprospecting applied to metabolism (GEBBAM), Federal University of Grande Dourados, Rodovia Dourados-Itahum, Km 12, Dourados 79804-970, MS, BrazilFruits are sources of bioactive compounds that are responsible for several biological activities. Therefore, this study aimed to identify the chemical composition of the pulp of the Brazilian Savanna fruit <i>Dipteryx alata</i>; evaluate its toxic effects, influence on the life expectancy of the nematode <i>Caenorhabditis elegans</i>, and its antioxidant activities in vitro and in vivo; and describe the mechanisms involved. The chemical compounds identified include phenols, terpenes, fatty acid derivatives, vitamins, and a carboxylic acid. The in vitro antioxidant activity was demonstrated by radical scavenging methods. in vivo, the <i>D. alata</i> fruit pulp was not toxic and promoted resistance to oxidative stress in nematodes exposed to a chemical oxidizing agent. Furthermore, it promoted an increased life expectancy in wild-type nematodes and increased the expression of superoxide dismutase and the nuclear translocation of DAF-16. These results suggest that the beneficial effects identified are related to these two genes, which are involved in the regulation of metabolic activities, the control of oxidative stress, and the lifespan <i>of C. elegans</i>. These beneficial effects, which may be related to its chemical constituents, demonstrate its potential use as a functional and/or nutraceutical food.https://www.mdpi.com/2218-273X/10/8/1106fruit nativeantioxidantprotects effects<i>C. elegans</i>nutraceutical food |
| spellingShingle | Natasha Rios Leite Laura Costa Alves de Araújo Paola dos Santos da Rocha Danielle Araujo Agarrayua Daiana Silva Ávila Carlos Alexandre Carollo Denise Brentan Silva Leticia Miranda Estevinho Kely de Picoli Souza Edson Lucas dos Santos Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16 Biomolecules fruit native antioxidant protects effects <i>C. elegans</i> nutraceutical food |
| title | Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16 |
| title_full | Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16 |
| title_fullStr | Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16 |
| title_full_unstemmed | Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16 |
| title_short | Baru Pulp (<i>Dipteryx alata</i> Vogel): Fruit from the Brazilian Savanna Protects against Oxidative Stress and Increases the Life Expectancy of <i>Caenorhabditis elegans</i> via SOD-3 and DAF-16 |
| title_sort | baru pulp i dipteryx alata i vogel fruit from the brazilian savanna protects against oxidative stress and increases the life expectancy of i caenorhabditis elegans i via sod 3 and daf 16 |
| topic | fruit native antioxidant protects effects <i>C. elegans</i> nutraceutical food |
| url | https://www.mdpi.com/2218-273X/10/8/1106 |
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