Pathways for Genome Integrity in G2 Phase of the Cell Cycle
The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA damage response, which leads to DNA repair and ce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2012-11-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2218-273X/2/4/579 |
| _version_ | 1818542259014991872 |
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| author | Claus Storgaard Sørensen Tobias Menzel Arne Nedergaard Kousholt |
| author_facet | Claus Storgaard Sørensen Tobias Menzel Arne Nedergaard Kousholt |
| author_sort | Claus Storgaard Sørensen |
| collection | DOAJ |
| description | The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA damage response, which leads to DNA repair and cell cycle arrest. Cell cycle checkpoints provide the cell time to complete replication and repair the DNA damage before it can continue to the next cell cycle phase. The G2/M checkpoint plays an especially important role in ensuring the propagation of error-free copies of the genome to each daughter cell. Here, we review recent progress in our understanding of DNA repair and checkpoint pathways in late S and G2 phases. This review will first describe the current understanding of normal cell cycle progression through G2 phase to mitosis. It will also discuss the DNA damage response including cell cycle checkpoint control and DNA double-strand break repair. Finally, we discuss the emerging concept that DNA repair pathways play a major role in the G2/M checkpoint pathway thereby blocking cell division as long as DNA lesions are present. |
| first_indexed | 2024-12-11T22:19:44Z |
| format | Article |
| id | doaj.art-7c6062dea8654508a07a17934612fa83 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-11T22:19:44Z |
| publishDate | 2012-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7c6062dea8654508a07a17934612fa832022-12-22T00:48:29ZengMDPI AGBiomolecules2218-273X2012-11-012457960710.3390/biom2040579Pathways for Genome Integrity in G2 Phase of the Cell CycleClaus Storgaard SørensenTobias MenzelArne Nedergaard KousholtThe maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA damage response, which leads to DNA repair and cell cycle arrest. Cell cycle checkpoints provide the cell time to complete replication and repair the DNA damage before it can continue to the next cell cycle phase. The G2/M checkpoint plays an especially important role in ensuring the propagation of error-free copies of the genome to each daughter cell. Here, we review recent progress in our understanding of DNA repair and checkpoint pathways in late S and G2 phases. This review will first describe the current understanding of normal cell cycle progression through G2 phase to mitosis. It will also discuss the DNA damage response including cell cycle checkpoint control and DNA double-strand break repair. Finally, we discuss the emerging concept that DNA repair pathways play a major role in the G2/M checkpoint pathway thereby blocking cell division as long as DNA lesions are present.http://www.mdpi.com/2218-273X/2/4/579genome integrityIRDNA damage checkpointG2/M transitionDNA repair |
| spellingShingle | Claus Storgaard Sørensen Tobias Menzel Arne Nedergaard Kousholt Pathways for Genome Integrity in G2 Phase of the Cell Cycle Biomolecules genome integrity IR DNA damage checkpoint G2/M transition DNA repair |
| title | Pathways for Genome Integrity in G2 Phase of the Cell Cycle |
| title_full | Pathways for Genome Integrity in G2 Phase of the Cell Cycle |
| title_fullStr | Pathways for Genome Integrity in G2 Phase of the Cell Cycle |
| title_full_unstemmed | Pathways for Genome Integrity in G2 Phase of the Cell Cycle |
| title_short | Pathways for Genome Integrity in G2 Phase of the Cell Cycle |
| title_sort | pathways for genome integrity in g2 phase of the cell cycle |
| topic | genome integrity IR DNA damage checkpoint G2/M transition DNA repair |
| url | http://www.mdpi.com/2218-273X/2/4/579 |
| work_keys_str_mv | AT clausstorgaardsørensen pathwaysforgenomeintegritying2phaseofthecellcycle AT tobiasmenzel pathwaysforgenomeintegritying2phaseofthecellcycle AT arnenedergaardkousholt pathwaysforgenomeintegritying2phaseofthecellcycle |