Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark
<abstract language="eng">The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2009-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000900002 |
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| author | Érica L. Santos Emmanoel V. Costa Francisco A. Marques Nelissa P. Vaz Beatriz Helena L. N. Sales Maia Eva G. Magalhães Ana Maria A. Tozzi |
| author_facet | Érica L. Santos Emmanoel V. Costa Francisco A. Marques Nelissa P. Vaz Beatriz Helena L. N. Sales Maia Eva G. Magalhães Ana Maria A. Tozzi |
| author_sort | Érica L. Santos |
| collection | DOAJ |
| description | <abstract language="eng">The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (¹H and 13C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes. |
| first_indexed | 2024-12-23T11:42:24Z |
| format | Article |
| id | doaj.art-7c60cfb7de1040f08ba1664d4e580006 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-23T11:42:24Z |
| publishDate | 2009-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-7c60cfb7de1040f08ba1664d4e5800062022-12-21T17:48:27ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642009-01-013292255225810.1590/S0100-40422009000900002Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root barkÉrica L. SantosEmmanoel V. CostaFrancisco A. MarquesNelissa P. VazBeatriz Helena L. N. Sales MaiaEva G. MagalhãesAna Maria A. Tozzi<abstract language="eng">The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (¹H and 13C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000900002Lonchocarpus filipesflavonoidsdibenzoylmethanes |
| spellingShingle | Érica L. Santos Emmanoel V. Costa Francisco A. Marques Nelissa P. Vaz Beatriz Helena L. N. Sales Maia Eva G. Magalhães Ana Maria A. Tozzi Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark Química Nova Lonchocarpus filipes flavonoids dibenzoylmethanes |
| title | Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark |
| title_full | Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark |
| title_fullStr | Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark |
| title_full_unstemmed | Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark |
| title_short | Toxicidade e atividade antioxidante de flavonoides das cascas das raízes de Lonchocarpus filipes Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark |
| title_sort | toxicidade e atividade antioxidante de flavonoides das cascas das raizes de lonchocarpus filipes toxicity and antioxidant activity of flavonoids from lonchocarpus filipes root bark |
| topic | Lonchocarpus filipes flavonoids dibenzoylmethanes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422009000900002 |
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