Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study
Background: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two. Methods: Participants were enrolled from Medical Informatio...
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
| प्रकाशित: |
Society of Medical Biochemists of Serbia, Belgrade
2024-01-01
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| श्रृंखला: | Journal of Medical Biochemistry |
| विषय: | |
| ऑनलाइन पहुंच: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401153J.pdf |
| _version_ | 1827355356476473344 |
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| author | Jin Zihan Xiao Lu Xu Xinyi Miao Changhong Liu Yi |
| author_facet | Jin Zihan Xiao Lu Xu Xinyi Miao Changhong Liu Yi |
| author_sort | Jin Zihan |
| collection | DOAJ |
| description | Background: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two. Methods: Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model. Results: Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk (odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P < 0.001). Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk (OR = 2.99, 95% CI = 1.64 to 5.46, P < 0.001). The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313). Conclusion: In patients with AMI, the incidence of TyG and AKI is closely related. Nevertheless, further studies are needed to verify the finding. |
| first_indexed | 2024-03-08T04:10:35Z |
| format | Article |
| id | doaj.art-7c6461ec7a294310b51b7e3b8d9e11e2 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-08T04:10:35Z |
| publishDate | 2024-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-7c6461ec7a294310b51b7e3b8d9e11e22024-02-08T22:37:03ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662024-01-0143115316110.5937/jomb0-452191452-82582401153JAssociation between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional studyJin Zihan0Xiao Lu1Xu Xinyi2Miao Changhong3Liu Yi4Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaUniversity of Traditional Chinese Medicine, First Teaching Hospital of Tianjin, Tianjin, ChinaUniversity of Traditional Chinese Medicine, First Teaching Hospital of Tianjin, Tianjin, ChinaUniversity of Traditional Chinese Medicine, First Teaching Hospital of Tianjin, Tianjin, ChinaUniversity of Traditional Chinese Medicine, First Teaching Hospital of Tianjin, Tianjin, ChinaBackground: The relationship between triglyceride glucose (TyG) index and the incidence of acute kidney injury (AKI) in patients with acute myocardial infarction (AMI) is unclear. This study aims to explore the relationship between the two. Methods: Participants were enrolled from Medical Information Mart for Intensive Care IV (MIMICIV) and grouping of subjects based on the quartile interval of the TyG index. With the presence of AKI as the main outcome, a logistic regression model was constructed. The correlation of the TyG index with the results obtained was examined by using a restricted cubic spline (RCS) model. Results: Among the 1,101 AMI participants, 64.7% were male patients and the overall incidence rate of AKI was 37.1%. The results of multivariate Logistic regression analysis (LRA) revealed independent correlation of the TyG index with increased AKI risk (odds ratio (OR) = 2.23; confidence interval (CI) = 1.59 to 3.17; P < 0.001). Q4 (9.5-12.208) in the TyG index quartile was independently correlated with increased AKI risk (OR = 2.99, 95% CI = 1.64 to 5.46, P < 0.001). The RCS model showed that the AKI risk increased linearly as the TyG index increased (P=0.313). Conclusion: In patients with AMI, the incidence of TyG and AKI is closely related. Nevertheless, further studies are needed to verify the finding.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401153J.pdfacute kidney injury (aki)triglyceride glucose index (tyg)acute myocardial infarction (ami)medical information mart for intensive care (mimic) |
| spellingShingle | Jin Zihan Xiao Lu Xu Xinyi Miao Changhong Liu Yi Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study Journal of Medical Biochemistry acute kidney injury (aki) triglyceride glucose index (tyg) acute myocardial infarction (ami) medical information mart for intensive care (mimic) |
| title | Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study |
| title_full | Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study |
| title_fullStr | Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study |
| title_full_unstemmed | Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study |
| title_short | Association between triglyceride-glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database: A cross-sectional study |
| title_sort | association between triglyceride glucose index and acute kidney injury in patients with acute myocardial infarction based on medical information mart for intensive care database a cross sectional study |
| topic | acute kidney injury (aki) triglyceride glucose index (tyg) acute myocardial infarction (ami) medical information mart for intensive care (mimic) |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2024/1452-82582401153J.pdf |
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