Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer
Biliary tract cancers (BTCs), including cholangiocarcinoma (CCA) and gallbladder cancer (GC), are malignancies originating from the biliary tract with poor prognosis. In the early stage of BTCs, surgery is the only choice for cure. Unfortunately, most patients with BTC are diagnosed at an advanced s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.777617/full |
| _version_ | 1818739092704198656 |
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| author | Yue Wang Tianli Chen Kangshuai Li Wentao Mu Zengli Liu Anda Shi Jialiang Liu Wei Zhao Shuo Lian Shaohui Huang Chang Pan Zongli Zhang |
| author_facet | Yue Wang Tianli Chen Kangshuai Li Wentao Mu Zengli Liu Anda Shi Jialiang Liu Wei Zhao Shuo Lian Shaohui Huang Chang Pan Zongli Zhang |
| author_sort | Yue Wang |
| collection | DOAJ |
| description | Biliary tract cancers (BTCs), including cholangiocarcinoma (CCA) and gallbladder cancer (GC), are malignancies originating from the biliary tract with poor prognosis. In the early stage of BTCs, surgery is the only choice for cure. Unfortunately, most patients with BTC are diagnosed at an advanced stage and lose the opportunity for surgery. For many advanced solid tumors, antiangiogenic therapy has achieved encouraging results. While most clinical studies on antiangiogenic therapy in advanced BTCs have shown an excellent disease control rate (DCR), the improvement in overall survival (OS) is controversial. Understanding how the relevant signaling molecules influence the angiogenic response and the functional interaction is necessary for the formulation of new treatment regimens and the selection of enrolled patients. In this review, we aim to summarize and discuss the latest advances in antiangeogenesis for BTCs, mainly focusing on the molecular mechanism of angiogenesis in BTCs and the therapeutic effects from clinical trials. Furthermore, the horizon of antiangiogenesis for BTCs is highlighted. |
| first_indexed | 2024-12-18T01:19:20Z |
| format | Article |
| id | doaj.art-7c6535e500ba497491e61e0174cadf4c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-18T01:19:20Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7c6535e500ba497491e61e0174cadf4c2022-12-21T21:25:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-10-011110.3389/fonc.2021.777617777617Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract CancerYue Wang0Tianli Chen1Kangshuai Li2Wentao Mu3Zengli Liu4Anda Shi5Jialiang Liu6Wei Zhao7Shuo Lian8Shaohui Huang9Chang Pan10Zongli Zhang11Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Emergency, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaBiliary tract cancers (BTCs), including cholangiocarcinoma (CCA) and gallbladder cancer (GC), are malignancies originating from the biliary tract with poor prognosis. In the early stage of BTCs, surgery is the only choice for cure. Unfortunately, most patients with BTC are diagnosed at an advanced stage and lose the opportunity for surgery. For many advanced solid tumors, antiangiogenic therapy has achieved encouraging results. While most clinical studies on antiangiogenic therapy in advanced BTCs have shown an excellent disease control rate (DCR), the improvement in overall survival (OS) is controversial. Understanding how the relevant signaling molecules influence the angiogenic response and the functional interaction is necessary for the formulation of new treatment regimens and the selection of enrolled patients. In this review, we aim to summarize and discuss the latest advances in antiangeogenesis for BTCs, mainly focusing on the molecular mechanism of angiogenesis in BTCs and the therapeutic effects from clinical trials. Furthermore, the horizon of antiangiogenesis for BTCs is highlighted.https://www.frontiersin.org/articles/10.3389/fonc.2021.777617/fullangiogenesisgallbladder carcinomabiliary tract cancerscholangiocarcinomatargeted therapymechanism |
| spellingShingle | Yue Wang Tianli Chen Kangshuai Li Wentao Mu Zengli Liu Anda Shi Jialiang Liu Wei Zhao Shuo Lian Shaohui Huang Chang Pan Zongli Zhang Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer Frontiers in Oncology angiogenesis gallbladder carcinoma biliary tract cancers cholangiocarcinoma targeted therapy mechanism |
| title | Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer |
| title_full | Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer |
| title_fullStr | Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer |
| title_full_unstemmed | Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer |
| title_short | Recent Advances in the Mechanism Research and Clinical Treatment of Anti-Angiogenesis in Biliary Tract Cancer |
| title_sort | recent advances in the mechanism research and clinical treatment of anti angiogenesis in biliary tract cancer |
| topic | angiogenesis gallbladder carcinoma biliary tract cancers cholangiocarcinoma targeted therapy mechanism |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.777617/full |
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