Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes
Aim. To evaluate the effects of myocardial cytoprotectors on the levels of apoptotic endotheliocytes and membranederived microparticles of endothelial origin in peripheral blood of the patients with cardiovascular disease (CVD). Material and methods. The study included CVD patients with arterial hyp...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
1970-01-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2177 |
| _version_ | 1797882813977985024 |
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| author | A. I. Inzhutova |
| author_facet | A. I. Inzhutova |
| author_sort | A. I. Inzhutova |
| collection | DOAJ |
| description | Aim. To evaluate the effects of myocardial cytoprotectors on the levels of apoptotic endotheliocytes and membranederived microparticles of endothelial origin in peripheral blood of the patients with cardiovascular disease (CVD). Material and methods. The study included CVD patients with arterial hypertension (AH) and coronary heart disease (CHD) or AH only, all of whom gave informed consent. The control group (CG) included patients with neuro-circulatory dystonia (NCD). In all participants, peripheral blood samples were taken at baseline and after 3 weeks of trimetazidine MR therapy, to assess the levels of endotheliocytes and membrane-derived microparticles. Results. Trimetazidine MR treatment resulted in significantly reduced levels of apoptotic endotheliocytes and membrane-derived microparticles in the two main groups and the CG (p<0,05). Conclusion. Trimetazidine MR could be used as pathogenetic therapy, correcting vascular wall homeostasis in CVD patients, and also as prevention of endothelial dysfunction progression in NCD patients. |
| first_indexed | 2024-04-10T03:41:43Z |
| format | Article |
| id | doaj.art-7c674abddd2a4919843092ed6d036d75 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:41:43Z |
| publishDate | 1970-01-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-7c674abddd2a4919843092ed6d036d752023-03-13T07:23:10Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01251970-01-019829321886Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytesA. I. Inzhutova0НИИ молекулярной медицины и патобиохимии Красноярского государственного медицинского университета им. проф. В.Ф. Войно-Ясенецкого. КрасноярскAim. To evaluate the effects of myocardial cytoprotectors on the levels of apoptotic endotheliocytes and membranederived microparticles of endothelial origin in peripheral blood of the patients with cardiovascular disease (CVD). Material and methods. The study included CVD patients with arterial hypertension (AH) and coronary heart disease (CHD) or AH only, all of whom gave informed consent. The control group (CG) included patients with neuro-circulatory dystonia (NCD). In all participants, peripheral blood samples were taken at baseline and after 3 weeks of trimetazidine MR therapy, to assess the levels of endotheliocytes and membrane-derived microparticles. Results. Trimetazidine MR treatment resulted in significantly reduced levels of apoptotic endotheliocytes and membrane-derived microparticles in the two main groups and the CG (p<0,05). Conclusion. Trimetazidine MR could be used as pathogenetic therapy, correcting vascular wall homeostasis in CVD patients, and also as prevention of endothelial dysfunction progression in NCD patients.https://cardiovascular.elpub.ru/jour/article/view/2177эндотелиальная дисфункцияапоптозмембран-высвобожденные микрочастицытриметазидин мв |
| spellingShingle | A. I. Inzhutova Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes Кардиоваскулярная терапия и профилактика эндотелиальная дисфункция апоптоз мембран-высвобожденные микрочастицы триметазидин мв |
| title | Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes |
| title_full | Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes |
| title_fullStr | Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes |
| title_full_unstemmed | Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes |
| title_short | Myocardial cytoprotectors demonstrate anti-apoptotic effect on vascular endotheliocytes |
| title_sort | myocardial cytoprotectors demonstrate anti apoptotic effect on vascular endotheliocytes |
| topic | эндотелиальная дисфункция апоптоз мембран-высвобожденные микрочастицы триметазидин мв |
| url | https://cardiovascular.elpub.ru/jour/article/view/2177 |
| work_keys_str_mv | AT aiinzhutova myocardialcytoprotectorsdemonstrateantiapoptoticeffectonvascularendotheliocytes |