Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice

Rapamycin improves peripheral nerve myelination while it fails to benefit neuromuscular performance in neuropathic mice

Charcot–-Marie–Tooth disease type 1A (CMT1A) is a hereditary peripheral neuropathy characterized by progressive demyelination and distal muscle weakness. Abnormal expression of peripheral myelin protein 22 (PMP22) has been linked to CMT1A and is modeled by Trembler J (TrJ) mice, which carry the same...

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Bibliographic Details
Main Authors: Jessica Nicks, Sooyeon Lee, Andrew Harris, Darin J. Falk, Adrian G. Todd, Karla Arredondo, William A. Dunn, Jr., Lucia Notterpek
Format: Article
Language:English
Published: Elsevier 2014-10-01
Series:Neurobiology of Disease
Subjects:
Demyelination
Autophagy
Schwann cell
Myelin
Trembler J
Charcot–Marie–Tooth disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114001879

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