Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study
Background: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2023-01-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/33/1/33_JE20210007/_pdf |
| _version_ | 1797960819270483968 |
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| author | Koshi Nakamura Shu-Ping Hui Shigekazu Ukawa Emiko Okada Takafumi Nakagawa Akihiro Imae Hiroaki Okabe Zhen Chen Yusuke Miura Hitoshi Chiba Akiko Tamakoshi |
| author_facet | Koshi Nakamura Shu-Ping Hui Shigekazu Ukawa Emiko Okada Takafumi Nakagawa Akihiro Imae Hiroaki Okabe Zhen Chen Yusuke Miura Hitoshi Chiba Akiko Tamakoshi |
| author_sort | Koshi Nakamura |
| collection | DOAJ |
| description | Background: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D3 (25[OH]D3) insufficiency. Methods: The present cross-sectional study compared the prevalence of diabetes, defined as a fasting plasma glucose level ≥126 mg/dL and/or a HbA1c level ≥6.5%, among 480 participants aged 35–79 years not taking anti-diabetes medications, based on serum 25(OH)D3 levels. A logistic regression model was used to calculate the odds ratios for diabetes in each serum 25(OH)D3 group. Furthermore, this study examined the association between serum 25(OH)D3 levels and the index of homeostasis model assessment of insulin resistance (HOMA-IR) using a linear regression model. Results: The prevalence of diabetes was 7.29% in the study population, and was higher in lower serum 25(OH)D3 quartile groups. The odds ratios for diabetes in the first, second, and third serum 25(OH)D3 quartile groups (25[OH]D3: ≤18.10, 18.11–22.90, and 22.91–28.17 ng/mL) were 4.02 (95% confidence interval [CI], 1.25–12.92), 2.50 (95% CI, 0.77–8.10), and 1.91 (95% CI, 0.60–6.09), respectively, with the fourth quartile group (⩾28.18 ng/mL) serving as the reference group, after adjusting for sociodemographic, lifestyle, physical and environmental factors. Serum 25(OH)D3 levels showed an inverse association with log-transformed HOMA-IR after adjusting for similar factors (standardized β = −0.08; 95% CI, −0.14 to −0.02). Conclusion: Serum 25(OH)D3 levels were inversely associated with diabetes prevalence in a general Japanese population, with a slight inverse association between serum 25(OH)D3 levels and HOMA-IR. |
| first_indexed | 2024-04-11T00:50:10Z |
| format | Article |
| id | doaj.art-7c681b9c8fe14562a096d2ee3481920d |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-04-11T00:50:10Z |
| publishDate | 2023-01-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-7c681b9c8fe14562a096d2ee3481920d2023-01-05T09:09:12ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922023-01-01331313710.2188/jea.JE20210007Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health StudyKoshi Nakamura0Shu-Ping Hui1Shigekazu Ukawa2Emiko Okada3Takafumi Nakagawa4Akihiro Imae5Hiroaki Okabe6Zhen Chen7Yusuke Miura8Hitoshi Chiba9Akiko Tamakoshi10Department of Public Health and Hygiene, Graduate School of Medicine, University of the Ryukyus, Okinawa, JapanFaculty of Health Sciences, Hokkaido University, Sapporo, JapanDepartment of Public Health, Hokkaido University Faculty of Medicine, Sapporo, JapanDepartment of Public Health, Hokkaido University Faculty of Medicine, Sapporo, JapanThe Hokkaido Centre for Family Medicine, Sapporo, JapanSuttu Municipal Clinic, Hokkaido, JapanFaculty of Health Sciences, Hokkaido University, Sapporo, JapanFaculty of Health Sciences, Hokkaido University, Sapporo, JapanSchool of Medical Technology, Faculty of Health Science, Gunma Paz University, Takasaki, JapanDepartment of Nutrition, Sapporo University of Health Sciences, Sapporo, JapanDepartment of Public Health, Hokkaido University Faculty of Medicine, Sapporo, JapanBackground: Both decreased insulin sensitivity and impaired insulin secretion are common in Asian populations with diabetes, in contrast to Western populations. There is limited evidence regarding the association between insulin response in diabetes in Asian populations and serum 25-hydroxyvitamin D3 (25[OH]D3) insufficiency. Methods: The present cross-sectional study compared the prevalence of diabetes, defined as a fasting plasma glucose level ≥126 mg/dL and/or a HbA1c level ≥6.5%, among 480 participants aged 35–79 years not taking anti-diabetes medications, based on serum 25(OH)D3 levels. A logistic regression model was used to calculate the odds ratios for diabetes in each serum 25(OH)D3 group. Furthermore, this study examined the association between serum 25(OH)D3 levels and the index of homeostasis model assessment of insulin resistance (HOMA-IR) using a linear regression model. Results: The prevalence of diabetes was 7.29% in the study population, and was higher in lower serum 25(OH)D3 quartile groups. The odds ratios for diabetes in the first, second, and third serum 25(OH)D3 quartile groups (25[OH]D3: ≤18.10, 18.11–22.90, and 22.91–28.17 ng/mL) were 4.02 (95% confidence interval [CI], 1.25–12.92), 2.50 (95% CI, 0.77–8.10), and 1.91 (95% CI, 0.60–6.09), respectively, with the fourth quartile group (⩾28.18 ng/mL) serving as the reference group, after adjusting for sociodemographic, lifestyle, physical and environmental factors. Serum 25(OH)D3 levels showed an inverse association with log-transformed HOMA-IR after adjusting for similar factors (standardized β = −0.08; 95% CI, −0.14 to −0.02). Conclusion: Serum 25(OH)D3 levels were inversely associated with diabetes prevalence in a general Japanese population, with a slight inverse association between serum 25(OH)D3 levels and HOMA-IR.https://www.jstage.jst.go.jp/article/jea/33/1/33_JE20210007/_pdf25-hydroxyvitamin d3diabetesinsulin resistancejapanese |
| spellingShingle | Koshi Nakamura Shu-Ping Hui Shigekazu Ukawa Emiko Okada Takafumi Nakagawa Akihiro Imae Hiroaki Okabe Zhen Chen Yusuke Miura Hitoshi Chiba Akiko Tamakoshi Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study Journal of Epidemiology 25-hydroxyvitamin d3 diabetes insulin resistance japanese |
| title | Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study |
| title_full | Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study |
| title_fullStr | Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study |
| title_full_unstemmed | Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study |
| title_short | Serum 25-hydroxyvitamin D3 Levels and Diabetes in a Japanese Population: The DOSANCO Health Study |
| title_sort | serum 25 hydroxyvitamin d3 levels and diabetes in a japanese population the dosanco health study |
| topic | 25-hydroxyvitamin d3 diabetes insulin resistance japanese |
| url | https://www.jstage.jst.go.jp/article/jea/33/1/33_JE20210007/_pdf |
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