Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved]
As the world’s population continues to age, an understanding of the aging brain becomes increasingly crucial. This review focuses on several recent ideas and findings in the study of neurocognitive aging, specifically focusing on episodic memory, and discusses how they can be considered and used to...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-04-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-491/v1 |
| _version_ | 1818239463842643968 |
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| author | Zachariah Reagh Michael Yassa |
| author_facet | Zachariah Reagh Michael Yassa |
| author_sort | Zachariah Reagh |
| collection | DOAJ |
| description | As the world’s population continues to age, an understanding of the aging brain becomes increasingly crucial. This review focuses on several recent ideas and findings in the study of neurocognitive aging, specifically focusing on episodic memory, and discusses how they can be considered and used to guide us moving forward. Topics include dysfunction in neural circuits, the roles of neurogenesis and inhibitory signaling, vulnerability in the entorhinal cortex, individual differences, and comorbidities. These avenues of study provide a brief overview of promising themes in the field and together provide a snapshot of what we believe will be important emerging topics in selective vulnerabilities in the aging brain. |
| first_indexed | 2024-12-12T12:57:57Z |
| format | Article |
| id | doaj.art-7c6a9777845843c4a8477b3c26282f12 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T12:57:57Z |
| publishDate | 2017-04-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-7c6a9777845843c4a8477b3c26282f122022-12-22T00:23:50ZengF1000 Research LtdF1000Research2046-14022017-04-01610.12688/f1000research.10652.111480Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved]Zachariah Reagh0Michael Yassa1Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USADepartment of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USAAs the world’s population continues to age, an understanding of the aging brain becomes increasingly crucial. This review focuses on several recent ideas and findings in the study of neurocognitive aging, specifically focusing on episodic memory, and discusses how they can be considered and used to guide us moving forward. Topics include dysfunction in neural circuits, the roles of neurogenesis and inhibitory signaling, vulnerability in the entorhinal cortex, individual differences, and comorbidities. These avenues of study provide a brief overview of promising themes in the field and together provide a snapshot of what we believe will be important emerging topics in selective vulnerabilities in the aging brain.https://f1000research.com/articles/6-491/v1AgingCognitive Neurology & DementiaCognitive NeuroscienceNeurobiology of Disease & RegenerationNeuronal & Glial Cell BiologyNeuronal Signaling Mechanisms |
| spellingShingle | Zachariah Reagh Michael Yassa Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved] F1000Research Aging Cognitive Neurology & Dementia Cognitive Neuroscience Neurobiology of Disease & Regeneration Neuronal & Glial Cell Biology Neuronal Signaling Mechanisms |
| title | Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved] |
| title_full | Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved] |
| title_fullStr | Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved] |
| title_full_unstemmed | Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved] |
| title_short | Selective vulnerabilities and biomarkers in neurocognitive aging [version 1; referees: 4 approved] |
| title_sort | selective vulnerabilities and biomarkers in neurocognitive aging version 1 referees 4 approved |
| topic | Aging Cognitive Neurology & Dementia Cognitive Neuroscience Neurobiology of Disease & Regeneration Neuronal & Glial Cell Biology Neuronal Signaling Mechanisms |
| url | https://f1000research.com/articles/6-491/v1 |
| work_keys_str_mv | AT zachariahreagh selectivevulnerabilitiesandbiomarkersinneurocognitiveagingversion1referees4approved AT michaelyassa selectivevulnerabilitiesandbiomarkersinneurocognitiveagingversion1referees4approved |