The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis
Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. Here, Tsukamoto et al. show that this effect is caused by a secreted protein that induces cell proliferation and angiogenesis by acting as an analog of the host’s vascular endothelial growth factor (VE...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17391-2 |
| _version_ | 1819036899988209664 |
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| author | Kentaro Tsukamoto Naoaki Shinzawa Akito Kawai Masahiro Suzuki Hiroyasu Kidoya Nobuyuki Takakura Hisateru Yamaguchi Toshiki Kameyama Hidehito Inagaki Hiroki Kurahashi Yasuhiko Horiguchi Yohei Doi |
| author_facet | Kentaro Tsukamoto Naoaki Shinzawa Akito Kawai Masahiro Suzuki Hiroyasu Kidoya Nobuyuki Takakura Hisateru Yamaguchi Toshiki Kameyama Hidehito Inagaki Hiroki Kurahashi Yasuhiko Horiguchi Yohei Doi |
| author_sort | Kentaro Tsukamoto |
| collection | DOAJ |
| description | Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. Here, Tsukamoto et al. show that this effect is caused by a secreted protein that induces cell proliferation and angiogenesis by acting as an analog of the host’s vascular endothelial growth factor (VEGF). |
| first_indexed | 2024-12-21T08:12:52Z |
| format | Article |
| id | doaj.art-7c6bada9dc8c434fa191c36a4398ea29 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T08:12:52Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7c6bada9dc8c434fa191c36a4398ea292022-12-21T19:10:37ZengNature PortfolioNature Communications2041-17232020-07-0111111410.1038/s41467-020-17391-2The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesisKentaro Tsukamoto0Naoaki Shinzawa1Akito Kawai2Masahiro Suzuki3Hiroyasu Kidoya4Nobuyuki Takakura5Hisateru Yamaguchi6Toshiki Kameyama7Hidehito Inagaki8Hiroki Kurahashi9Yasuhiko Horiguchi10Yohei Doi11Department of Microbiology, Fujita Health University School of MedicineDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Microbiology, Fujita Health University School of MedicineDepartment of Microbiology, Fujita Health University School of MedicineDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Signal Transduction, Research Institute for Microbial Diseases, Osaka UniversityDivision of Biomedical Polymer Science, Institute for Comprehensive Medical Science, Fujita Health UniversityDivision of Gene Expression Mechanism, Institute for Comprehensive Medical Science, Fujita Health UniversityDivision of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health UniversityDivision of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health UniversityDepartment of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka UniversityDepartment of Microbiology, Fujita Health University School of MedicinePathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. Here, Tsukamoto et al. show that this effect is caused by a secreted protein that induces cell proliferation and angiogenesis by acting as an analog of the host’s vascular endothelial growth factor (VEGF).https://doi.org/10.1038/s41467-020-17391-2 |
| spellingShingle | Kentaro Tsukamoto Naoaki Shinzawa Akito Kawai Masahiro Suzuki Hiroyasu Kidoya Nobuyuki Takakura Hisateru Yamaguchi Toshiki Kameyama Hidehito Inagaki Hiroki Kurahashi Yasuhiko Horiguchi Yohei Doi The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis Nature Communications |
| title | The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis |
| title_full | The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis |
| title_fullStr | The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis |
| title_full_unstemmed | The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis |
| title_short | The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis |
| title_sort | bartonella autotransporter bafa activates the host vegf pathway to drive angiogenesis |
| url | https://doi.org/10.1038/s41467-020-17391-2 |
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