A model for oxygen conservation associated with titration during pediatric oxygen therapy.
BACKGROUND:Continuous oxygen treatment is essential for managing children with hypoxemia, but access to oxygen in low-resource countries remains problematic. Given the high burden of pneumonia in these countries and the fact that flow can be gradually reduced as therapy progresses, oxygen conservati...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5325194?pdf=render |
| _version_ | 1818988381604937728 |
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| author | Grace Wu Alec Wollen Stephen Himley Glenn Austin Jaclyn Delarosa Rasa Izadnegahdar Amy Sarah Ginsburg Darin Zehrung |
| author_facet | Grace Wu Alec Wollen Stephen Himley Glenn Austin Jaclyn Delarosa Rasa Izadnegahdar Amy Sarah Ginsburg Darin Zehrung |
| author_sort | Grace Wu |
| collection | DOAJ |
| description | BACKGROUND:Continuous oxygen treatment is essential for managing children with hypoxemia, but access to oxygen in low-resource countries remains problematic. Given the high burden of pneumonia in these countries and the fact that flow can be gradually reduced as therapy progresses, oxygen conservation through routine titration warrants exploration. AIM:To determine the amount of oxygen saved via titration during oxygen therapy for children with hypoxemic pneumonia. METHODS:Based on published clinical data, we developed a model of oxygen flow rates needed to manage hypoxemia, assuming recommended flow rate at start of therapy, and comparing total oxygen used with routine titration every 3 minutes or once every 24 hours versus no titration. RESULTS:Titration every 3 minutes or every 24 hours provided oxygen savings estimated at 11.7% ± 5.1% and 8.1% ± 5.1% (average ± standard error of the mean, n = 3), respectively. For every 100 patients, 44 or 30 kiloliters would be saved-equivalent to 733 or 500 hours at 1 liter per minute. CONCLUSIONS:Ongoing titration can conserve oxygen, even performed once-daily. While clinical validation is necessary, these findings could provide incentive for the routine use of pulse oximeters for patient management, as well as further development of automated systems. |
| first_indexed | 2024-12-20T19:21:41Z |
| format | Article |
| id | doaj.art-7c6eb8101ea3491b92eda4faf749895a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T19:21:41Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7c6eb8101ea3491b92eda4faf749895a2022-12-21T19:28:58ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017153010.1371/journal.pone.0171530A model for oxygen conservation associated with titration during pediatric oxygen therapy.Grace WuAlec WollenStephen HimleyGlenn AustinJaclyn DelarosaRasa IzadnegahdarAmy Sarah GinsburgDarin ZehrungBACKGROUND:Continuous oxygen treatment is essential for managing children with hypoxemia, but access to oxygen in low-resource countries remains problematic. Given the high burden of pneumonia in these countries and the fact that flow can be gradually reduced as therapy progresses, oxygen conservation through routine titration warrants exploration. AIM:To determine the amount of oxygen saved via titration during oxygen therapy for children with hypoxemic pneumonia. METHODS:Based on published clinical data, we developed a model of oxygen flow rates needed to manage hypoxemia, assuming recommended flow rate at start of therapy, and comparing total oxygen used with routine titration every 3 minutes or once every 24 hours versus no titration. RESULTS:Titration every 3 minutes or every 24 hours provided oxygen savings estimated at 11.7% ± 5.1% and 8.1% ± 5.1% (average ± standard error of the mean, n = 3), respectively. For every 100 patients, 44 or 30 kiloliters would be saved-equivalent to 733 or 500 hours at 1 liter per minute. CONCLUSIONS:Ongoing titration can conserve oxygen, even performed once-daily. While clinical validation is necessary, these findings could provide incentive for the routine use of pulse oximeters for patient management, as well as further development of automated systems.http://europepmc.org/articles/PMC5325194?pdf=render |
| spellingShingle | Grace Wu Alec Wollen Stephen Himley Glenn Austin Jaclyn Delarosa Rasa Izadnegahdar Amy Sarah Ginsburg Darin Zehrung A model for oxygen conservation associated with titration during pediatric oxygen therapy. PLoS ONE |
| title | A model for oxygen conservation associated with titration during pediatric oxygen therapy. |
| title_full | A model for oxygen conservation associated with titration during pediatric oxygen therapy. |
| title_fullStr | A model for oxygen conservation associated with titration during pediatric oxygen therapy. |
| title_full_unstemmed | A model for oxygen conservation associated with titration during pediatric oxygen therapy. |
| title_short | A model for oxygen conservation associated with titration during pediatric oxygen therapy. |
| title_sort | model for oxygen conservation associated with titration during pediatric oxygen therapy |
| url | http://europepmc.org/articles/PMC5325194?pdf=render |
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